Transporter-Mediated Solutes Uptake as Drug Target in Plasmodium falciparum

Malaria remains a public health problem with still more than half a million deaths annually. Despite ongoing efforts of many countries, malaria elimination has been difficult due to emerging resistances against most traditional drugs, including artemisinin compounds - the most potent antimalarials c...

Full description

Saved in:
Bibliographic Details
Published in:Frontiers in pharmacology 2022-02, Vol.13, p.845841-845841
Main Authors: Monteiro Júnior, Júlio César, Krüger, Arne, Palmisano, Giuseppe, Wrenger, Carsten
Format: Article
Language:English
Subjects:
malaria
new drugs
P. falciparum
Pharmacology
resistance
solute uptake
transporters
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Malaria remains a public health problem with still more than half a million deaths annually. Despite ongoing efforts of many countries, malaria elimination has been difficult due to emerging resistances against most traditional drugs, including artemisinin compounds - the most potent antimalarials currently available. Therefore, the discovery and development of new drugs with novel mechanisms of action to circumvent resistances is urgently needed. In this sense, one of the most promising areas is the exploration of transport proteins. Transporters mediate solute uptake for intracellular parasite proliferation and survival. Targeting transporters can exploit these processes to eliminate the parasite. Here, we focus on transporters of the -infected red blood cell studied as potential biological targets and discuss published drugs directed at them.
ISSN:1663-9812
1663-9812
DOI:10.3389/fphar.2022.845841