DNA interference and beyond: structure and functions of prokaryotic Argonaute proteins

Recognition and repression of RNA targets by Argonaute proteins guided by small RNAs is the essence of RNA interference in eukaryotes. Argonaute proteins with diverse structures are also found in many bacterial and archaeal genomes. Recent studies revealed that, similarly to their eukaryotic counter...

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Bibliographic Details
Published in:Nature communications 2018-12, Vol.9 (1), p.5165-12, Article 5165
Main Authors: Lisitskaya, Lidiya, Aravin, Alexei A., Kulbachinskiy, Andrey
Format: Article
Language:English
Subjects:
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Argonaute Proteins - chemistry
Argonaute Proteins - genetics
Argonaute Proteins - physiology
Catalysis
Catalytic Domain
Deoxyribonucleic acid
DNA
DNA - physiology
DNA structure
Eukaryota - genetics
Eukaryota - physiology
Eukaryotes
Eukaryotic Cells - physiology
Genetic Engineering
Genomes
Humanities and Social Sciences
Immune System
Interference
multidisciplinary
Prokaryotic Cells - physiology
Protein Binding
Protein Domains
Protein Interaction Domains and Motifs
Proteins
Review
Review Article
Ribonucleic acid
RNA
RNA - physiology
RNA Interference - physiology
RNA, Small Interfering - physiology
RNA-mediated interference
Science
Science (multidisciplinary)
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Summary:Recognition and repression of RNA targets by Argonaute proteins guided by small RNAs is the essence of RNA interference in eukaryotes. Argonaute proteins with diverse structures are also found in many bacterial and archaeal genomes. Recent studies revealed that, similarly to their eukaryotic counterparts, prokaryotic Argonautes (pAgos) may function in cell defense against foreign genetic elements but, in contrast, preferably act on DNA targets. Many crucial details of the pAgo action, and the roles of a plethora of pAgos with non-conventional architecture remain unknown. Here, we review available structural and biochemical data on pAgos and discuss their possible functions in host defense and other genetic processes in prokaryotic cells. In this review, Aravin and colleagues examine bacterial and archaeal Argonaute proteins, discuss their diverse architectures and their possible roles in host defense, proposing additional functions for Argonaute proteins in prokaryotic cells.
ISSN:2041-1723
2041-1723
DOI:10.1038/s41467-018-07449-7