Moving beyond species: fungal function in house dust provides novel targets for potential indicators of mold growth in homes

Increased risk of asthma and other respiratory diseases is associated with exposures to microbial communities growing in damp and moldy indoor environments. The exact causal mechanisms remain unknown, and occupant health effects have not been consistently associated with any species-based mold measu...

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Bibliographic Details
Published in:Microbiome 2024-11, Vol.12 (1), p.231-17, Article 231
Main Authors: Balasubrahmaniam, Neeraja, King, Jon C, Hegarty, Bridget, Dannemiller, Karen C
Format: Article
Language:English
Subjects:
Air Microbiology
Air Pollution, Indoor
Analysis
Anopheles
Dampness
Dust - analysis
Fungi
Fungi - classification
Fungi - genetics
Gene expression
Gene Expression Regulation, Fungal
Genes
Genetic aspects
Growth
Health aspects
Housing
Humans
Humidity
Metabolites
Microbiome
Moisture
Molds (Fungi)
Mycobiome - genetics
Physiological aspects
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Summary:Increased risk of asthma and other respiratory diseases is associated with exposures to microbial communities growing in damp and moldy indoor environments. The exact causal mechanisms remain unknown, and occupant health effects have not been consistently associated with any species-based mold measurement methods. We need new quantitative methods to identify homes with potentially harmful fungal growth that are not dependent upon species. The goal of this study was to identify genes consistently associated with fungal growth and associated function under damp conditions for use as potential indicators of mold in homes regardless of fungal species present. A de novo metatranscriptomic analysis was performed using house dust from across the US, incubated at 50%, 85%, or 100% equilibrium relative humidity (ERH) for 1 week. Gene expression was a function of moisture (adonis2 p 
ISSN:2049-2618
2049-2618
DOI:10.1186/s40168-024-01915-9