Biomarkers in Contrast-Induced Acute Kidney Injury: Towards A New Perspective

Contrast-Induced Acute Kidney Injury (CI-AKI) remains a frequent iatrogenic condition since radiological procedures using intra-vascular iodinated contrast media (CM) are being widely administered for diagnostic and therapeutic purposes. Despite the improvement of the medical healthcare system world...

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Bibliographic Details
Published in:International journal of molecular sciences 2024-03, Vol.25 (6), p.3438
Main Authors: González-Nicolás, María Ángeles, González-Guerrero, Cristian, Goicoechea, Marian, Boscá, Lisardo, Valiño-Rivas, Lara, Lázaro, Alberto
Format: Article
Language:English
Subjects:
Acute Kidney Injury - chemically induced
Acute Kidney Injury - diagnosis
Albert, Marvin H
Analgesics
Apoptosis
Biological markers
Biomarkers
Cardiovascular diseases
Cell death
Chronic kidney failure
Clinical medicine
Contrast media
contrast-induced acute kidney injury
Creatinine
Drug-Related Side Effects and Adverse Reactions - complications
Fatalities
Health aspects
Humans
Iatrogenesis
Ischemia
Kidney
Kidney diseases
Kidney Failure, Chronic - complications
Mitochondria
Mortality
nephrotoxicity
Oliguria
Physiology
Review
Risk Factors
Sepsis
Spain
Trauma
Viscosity
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Summary:Contrast-Induced Acute Kidney Injury (CI-AKI) remains a frequent iatrogenic condition since radiological procedures using intra-vascular iodinated contrast media (CM) are being widely administered for diagnostic and therapeutic purposes. Despite the improvement of the medical healthcare system worldwide, CI-AKI is still associated with direct short-term and indirect long-term outcomes including increased morbidity and mortality, especially in patients with underlying pre-existing renal function impairment, cardiovascular disease, or diabetes that could rapidly progress into Chronic Kidney Disease. Although the RIFLE (Risk, Injury, Failure, Loss, End-Stage Kidney Disease), AKIN (Acute Kidney Injury Network), and KDIGO (Kidney Disease Improving Global Outcomes) clinical criteria and recommendation guidelines are based on traditional "gold standard" biomarkers known as serum creatinine, glomerular filtration rate, and urinary output, new reliable serum and urinary biomarkers are still needed for an effective unified diagnostic strategy for AKI. Starting from previous and recent publications on the benefits and limitations of validated biomarkers responding to kidney injury, glomerular filtration, and inflammation among others, this review unravels the role of new emerging biomarkers used alone or in combination as reliable tools for early diagnosis and prognosis of CI-AKI, taking into account patients and procedures-risk factors towards a new clinical perspective.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms25063438