Osteoporosis is associated with elevated baseline cerebrospinal fluid biomarkers and accelerated brain structural atrophy among older people

Objective: Examine whether osteoporosis (OP) is associated with Alzheimer's disease-related cerebrospinal fluid (CSF) biomarkers and brain structures among older people. Methods: From the Alzheimer's Disease Neuroimaging Initiative database, we grouped participants according to the OP stat...

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Bibliographic Details
Published in:Frontiers in aging neuroscience 2022-09, Vol.14, p.958050-958050
Main Authors: Pan, Hao, Cao, Jiali, Wu, Congcong, Huang, Furong, Wu, Peng, Lang, Junzhe, Liu, Yangbo
Format: Article
Language:English
Subjects:
Alzheimer's disease
Apolipoprotein E4
Atrophy
biomarker
Biomarkers
Cerebrospinal fluid
Cortex (entorhinal)
Cross-sectional studies
Data processing
entorhinal cortex
Hippocampus
Investigations
Longitudinal studies
Magnetic resonance imaging
Medical imaging
Neurodegenerative diseases
Neuroimaging
Neuroscience
Older people
Osteoporosis
Regression analysis
Tau protein
Threonine
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Summary:Objective: Examine whether osteoporosis (OP) is associated with Alzheimer's disease-related cerebrospinal fluid (CSF) biomarkers and brain structures among older people. Methods: From the Alzheimer's Disease Neuroimaging Initiative database, we grouped participants according to the OP status (OP+ / OP−) and compared the AD-related CSF biomarker levels and the regional brain structural volumes between the two groups using multivariable models. These models were adjusted for covariates including age, education, gender, diagnosis of Alzheimer's disease, and apolipoprotein E4 carrier status. Results: In the cross-sectional analyses at baseline, OP was related to higher CSF t-tau (total tau) and p-tau181 (tau phosphorylated at threonine-181) but not to CSF amyloid-beta (1-42) or the volumes of entorhinal cortex and hippocampus. In the longitudinal analyses, OP was not associated with the change in the three CSF biomarkers over time but was linked to a faster decline in the size of the entorhinal cortex and hippocampus. Conclusion: OP was associated with elevated levels of CSF t-tau and p-tau181 at baseline, as well as accelerated entorhinal cortex and hippocampal atrophies over time among older people.
ISSN:1663-4365
1663-4365
DOI:10.3389/fnagi.2022.958050