Extent of FLAIR Hyperintense Vessels May Modify Treatment Effect of Thrombolysis: A Post hoc Analysis of the WAKE-UP Trial

Fluid-attenuated inversion recovery (FLAIR) hyperintense vessels (FHVs) on MRI are a radiological marker of vessel occlusion and indirect sign of collateral circulation. However, the clinical relevance is uncertain. We explored whether the extent of FHVs is associated with outcome and how FHVs modif...

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Published in:Frontiers in neurology 2021-02, Vol.11 (6), p.623881-623881
Main Authors: Grosch, Anne Sophie, Kufner, Anna, Boutitie, Florent, Cheng, Bastian, Ebinger, Martin, Endres, Matthias, Fiebach, Jochen B, Fiehler, Jens, Königsberg, Alina, Lemmens, Robin, Muir, Keith W, Nighoghossian, Norbert, Pedraza, Salvador, Siemonsen, Claus Z, Thijs, Vincent, Wouters, Anke, Gerloff, Christian, Thomalla, Götz, Galinovic, Ivana
Format: Article
Language:English
Subjects:
FLAIR hyperintensities
ischemic stroke
MRI
Neurology
prognosis
Statistics
thrombolysis
wake-up stroke
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Summary:Fluid-attenuated inversion recovery (FLAIR) hyperintense vessels (FHVs) on MRI are a radiological marker of vessel occlusion and indirect sign of collateral circulation. However, the clinical relevance is uncertain. We explored whether the extent of FHVs is associated with outcome and how FHVs modify treatment effect of thrombolysis in a subgroup of patients with confirmed unilateral vessel occlusion from the randomized controlled WAKE-UP trial. One hundred sixty-five patients were analyzed. Two blinded raters independently assessed the presence and extent of FHVs (defined as the number of slices with visible FHV multiplied by FLAIR slice thickness). Patients were then separated into two groups to distinguish between few and extensive FHVs (dichotomization at the median
ISSN:1664-2295
1664-2295
DOI:10.3389/fneur.2020.623881