Editorial: Temperature-dependent mechanisms of neuron functioning: Emerging concepts

• Published in: Frontiers in cellular neuroscience 2022-08, Vol.16, p.1009071-1009071
• Main Authors: Korogod, Sergiy M., Tsagareli, Merab, Delmas, Patrick, Zholos, Alexander V.
• Format: Article
• Language: English
• Subjects: Biophysics; Brain research; Calcium channels; Calcium channels (voltage-gated); Calcium conductance; Cellular Neuroscience; Cold; excitability; Glutamic acid receptors; Ion channels; Life Sciences; Neurons; Potassium; Potassium channels (calcium-gated); Potassium channels (voltage-gated); Potassium conductance; Sensory neurons; Sodium channels (voltage-gated); spiking patterns; Temperature; thermosensing mechanisms; Transient receptor potential proteins; γ-Aminobutyric acid A receptors
• ISSN: 1662-5102; 1662-5102
• DOI: 10.3389/fncel.2022.1009071

Gotoh et al. found that cortical evoked potentials (CEPs) in anesthetized rats decreased in amplitude to nearly zero when the local brain temperature decreased below 17°C and, in contrast, increased with decreasing temperature from near-physiological level of 36°C to >17°C. The negative correlation of CEPs and local cortical temperatures remaining above 17°C was eliminated by the administration of a GABAA receptor antagonist. In the article by Buijs and McNaughton, the role of cold-sensitive TRP channels (TRPM8, TRPC5, and TRPA1) and cold-sensitive ion channels in sensory neurons are reviewed including two-pore domain potassium channel (K2P), glutamate receptor (GluK2), and cyclic nucleotide-gated ion channel (CNGA3). Maksymchuk et al. developed a quantitative mathematical/biophysical model that accounted for parallel activities of six different types of channels, including thermo-TRPs, voltage-gated Na+, K+, and Ca2+, and small- and large-conductance Ca2+-activated K+ channels in Drosophila larva cold-sensing Class III somatosensory neurons.