Clinical impact of videocapsule endoscopy and device-assisted enteroscopy in non-bleeding small bowel lesions

• Published in: Therapeutic advances in gastroenterology 2023-01, Vol.16, p.17562848231176424-17562848231176424
• Main Authors: Topa, Matilde, Nandi, Nicoletta, Scaramella, Lucia, Puricelli, Michele, Pennazio, Marco, Sidhu, Reena, Sanders, David S., Tontini, Gian Eugenio, Penagini, Roberto, Vecchi, Maurizio, Elli, Luca
• Format: Article
• Language: English
• Subjects: Celiac disease; Endoscopy; Gastroenterology; Original Research
• ISSN: 1756-2848; 1756-283X; 1756-2848
• DOI: 10.1177/17562848231176424

Background: Videocapsule endoscopy (VCE) and double-balloon enteroscopy (DBE) are part of the diagnostic and therapeutic work-up of indications other than suspected small bowel bleeding (OSBB). The literature is currently lacking studies describing these procedures in this particular setting. Objectives: We assessed the clinical impact of VCE and DBE in a large monocentric cohort of OSBB patients, as compared to a control group of suspected small bowel bleeding (SSBB) patients who underwent enteroscopy over the same period. Design: Monocentric, retrospective, cohort study. Methods: We collected the data of consecutive patients with OSBB undergoing VCE and/or DBE from March 2001 to July 2020. The demographic and clinical parameters of the patients, technical characteristics, and adverse events for each procedure were collected. The impact of VCE and DBE was defined in terms of diagnostic yield (DY). The patients were subdivided according to the main indication into four groups: celiac disease, Crohn’s disease (CD), neoplasia, and persistent gastrointestinal symptoms. Results: A total of 611 VCEs and 387 DBEs were performed for OSBB. The main indications were complicated celiac disease and CD. The DYs of VCE and DBE overall were 53 and 61.7%, respectively, with some variance among the four groups. We report no statistical differences in the DY of VCE and DBE in SSBB vs OSBB (57.7% vs 53%, p = 0.0859 and 68.8% vs 61.7%, p = 0.0582, respectively). OSBB patients were significantly younger than those with SSBB. However, similarly to SSBB (k = 0.059), poor agreement between the enteroscopic techniques was found in the OSBB population (k = 0.109). The safety of both procedures in OSBB was comparable to that in SSBB patients. Conclusion: VCE and DBE are effective and safe in suspected OSBB, where their role is similar to that in SSBB, their main indication.