Correlational research on facial and clinical characteristics of adolescents with obsessive-compulsive disorder

The neurodevelopmental model of obsessive-compulsive disorder (OCD) suggests that the neurodevelopmental changes in the ventral striatal circuit of the prefrontal lobe are associated with the initial symptoms of OCD. Facial morphology is one of the most consistent anatomical phenotypes of neurodevel...

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Bibliographic Details
Published in:BMC psychiatry 2021-12, Vol.21 (1), p.623-623, Article 623
Main Authors: Wang, Yan-Rong, Chang, Shao-Hua, Ma, Xiao-Min, Li, Ji-Ying, Zhang, Rui-Xia, Fang, Jian-Qun
Format: Article
Language:English
Subjects:
Adolescent
Adolescents
Attention deficit hyperactivity disorder
Autism
Brain
Brain research
Child & adolescent psychiatry
Child psychopathology
Children & youth
Complications and side effects
Correlational studies
Craniofacial abnormalities
Demographic aspects
Facial characteristics
Female
Functional anatomy
Health aspects
Humans
Lip
Male
Morphology
Neostriatum
Neurodevelopment
Neurodevelopmental disorders
Obsessive compulsive disorder
Obsessive-Compulsive Disorder - diagnosis
Patients
Pediatric research
Pediatrics
Phenotypes
Physiological aspects
Plastic surgery
Psychiatry
Psychological aspects
Risk factors
Schizophrenia
Structure-function relationships
Teenagers
Youth
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Summary:The neurodevelopmental model of obsessive-compulsive disorder (OCD) suggests that the neurodevelopmental changes in the ventral striatal circuit of the prefrontal lobe are associated with the initial symptoms of OCD. Facial morphology is one of the most consistent anatomical phenotypes of neurodevelopmental disorders, which can reflect brain structure and function. Facial deformity, an easily measured index of brain malformation, can reflect abnormal brain structure and function. Therefore, this study aims to explore the relationship between clinical features and neurodevelopment of adolescents with OCD through facial morphology. The enrolled study sample comprised 40 adolescents diagnosed with OCD using the Obsessive Compulsive Inventory-Child Version (OCI-CV) and 38 healthy controls (HCs). Facial photos, 21 facial diameters, and 9 facial angles were collected using image software. In males, lower lip red height was significantly lower in OCD patients than in HCs (P  0.025). In females, the nasolabial angle was smaller in OCD patients than in HCs (P  0.025). The difference in lower lip red height between the OCD group and HC group was positively correlated with neutralizing symptoms (r = 0.401, P 
ISSN:1471-244X
1471-244X
DOI:10.1186/s12888-021-03612-5