Identifying and exploring the favorable factors that help to slow the progression of disease in patients with mild cervical spondylotic myelopathy

To explore the favorable factors that help slow the progression of disease in patients with mild Cervical Spondylotic Myelopathy (CSM). A retrospective analysis was conducted, involving the enrollment of 115 CSM patients. The categorization of patients into two groups was based on the duration of sy...

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Bibliographic Details
Published in:Scientific reports 2024-08, Vol.14 (1), p.18986-15, Article 18986
Main Authors: Lin, Taotao, Yao, Zhipeng, Xiao, Zhehao, Wu, Rongcan, Zhao, Yujie, Chen, Dehui, Zhou, Linquan, Wang, Zhenyu, Liu, Wenge
Format: Article
Language:English
Subjects:
631/1647/2258
692/617/375
692/698/1671
Adult
Aged
Canals (anatomy)
Central nervous system diseases
Cervical vertebra sagittal parameters
Cervical Vertebrae - diagnostic imaging
Cervical Vertebrae - pathology
Compression degree of the cervical spinal cord
Compression degree of the spinal canal
Disease Progression
Female
Humanities and Social Sciences
Humans
Male
Middle Aged
Mild cervical spondylotic myelopathy
multidisciplinary
Paravertebral muscle degeneration
Range of Motion, Articular
Regression analysis
Retrospective Studies
ROC Curve
Science
Science (multidisciplinary)
Severity of Illness Index
Slow disease progression
Spinal cord
Spinal Cord Compression - pathology
Spinal Cord Diseases - diagnostic imaging
Spinal Cord Diseases - pathology
Spondylosis - diagnostic imaging
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Summary:To explore the favorable factors that help slow the progression of disease in patients with mild Cervical Spondylotic Myelopathy (CSM). A retrospective analysis was conducted, involving the enrollment of 115 CSM patients. The categorization of patients into two groups was based on the duration of symptoms, assessments using the mJOA scale and Health Transition (HT) scores: mild-slow group and severe-rapid group. We found that the patients in both groups had similar degrees of spinal cord compression, but mild-slow group were older and had smaller C2–C7 cobb angle (Flexion) (CL(F)), C2–C7 cobb angle (Range of motion) (CL(ROM)), Transverse area (TA), Normal-TA, Compressive spinal canal area (CSCA), Normal-Spinal canal area (Normal-SCA) and lower Spinal cord increased signal intensity (ISI) Grade than the severe-rapid group. A binary logistic regression analysis showed that CL(ROM) and Normal-TA are favorable factors to help slow the progression of disease patients with mild CSM. Through ROC curves, we found that when CL(ROM) 
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-024-69899-y