Development of Vancomycin Delivery Systems Based on Autologous 3D Platelet-Rich Fibrin Matrices for Bone Tissue Engineering

Autologous platelet-rich fibrin (PRF) is derived from the blood and its use in the bone tissue engineering has emerged as an effective strategy for novel drug and growth factor delivery systems. Studies have approved that combined therapy with PRF ensures higher biological outcomes, but patients sti...

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Bibliographic Details
Published in:Biomedicines 2021-07, Vol.9 (7), p.814
Main Authors: Dubnika, Arita, Egle, Karina, Skrinda-Melne, Marite, Skadins, Ingus, Rajadas, Jayakumar, Salma, Ilze
Format: Article
Language:English
Subjects:
Antibacterial activity
Antibiotics
Biomaterials
Blood platelets
Cell culture
Cholesterol
drug delivery
Drug delivery systems
Efficiency
Fibrin
Growth factors
Hydration
Lipids
liposomes
Maxillofacial surgery
microcapsules
Microparticles
Oral administration
phospholipids
platelet-rich fibrin
Platelets
Polyvinyl alcohol
Thin films
Tissue engineering
Vancomycin
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Summary:Autologous platelet-rich fibrin (PRF) is derived from the blood and its use in the bone tissue engineering has emerged as an effective strategy for novel drug and growth factor delivery systems. Studies have approved that combined therapy with PRF ensures higher biological outcomes, but patients still undergo additional treatment with antibiotic drugs before, during, and even after the implantation of biomaterials with PRF. These systematically used drugs spread throughout the blood and lead not only to positive effects but may also induce adverse side effects on healthy tissues. Vancomycin hydrochloride (VANKA) is used to treat severe Staphylococcal infections but its absorption in the target tissue after oral administration is low; therefore, in this study, we have developed and analyzed two kinds of VANKA carriers—liposomes and microparticles in 3D PRF matrices. The adjustment, characterization, and analysis of VANKA carriers in 3D PRF scaffolds is carried out in terms of encapsulation efficiency, drug release kinetics and antibacterial activity; furthermore, we have studied the micro- and macrostructure of the scaffolds with microtomography.
ISSN:2227-9059
2227-9059
DOI:10.3390/biomedicines9070814