Genetic Variation and Autism: A Field Synopsis and Systematic Meta-Analysis

This study aimed to verify noteworthy findings between genetic risk factors and autism spectrum disorder (ASD) by employing the false positive report probability (FPRP) and the Bayesian false-discovery probability (BFDP). PubMed and the Genome-Wide Association Studies (GWAS) catalog were searched fr...

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Bibliographic Details
Published in:Brain sciences 2020-10, Vol.10 (10), p.1
Main Authors: Lee, Jinhee, Son, Min Ji, Son, Chei Yun, Jeong, Gwang Hun, Lee, Keum Hwa, Lee, Kwang Seob, Ko, Younhee, Kim, Jong Yeob, Lee, Jun Young, Radua, Joaquim, Eisenhut, Michael, Gressier, Florence, Koyanagi, Ai, Stubbs, Brendon, Solmi, Marco, Rais, Theodor B, Kronbichler, Andreas, Dragioti, Elena, Vasconcelos, Daniel Fernando Pereira, Silva, Felipe Rodolfo Pereira da, Tizaoui, Kalthoum, Brunoni, André Russowsky, Carvalho, Andre F, Cargnin, Sarah, Terrazzino, Salvatore, Stickley, Andrew, Smith, Lee, Thompson, Trevor, Shin, Jae Il, Fusar-Poli, Paolo
Format: Article
Language:English
Subjects:
Autism
autism spectrum disorder
Bayesian false-discovery probability (BFDP)
false positive report probability (FPRP)
Genetic aspects
Genetic variation
Genome-Wide Association Studies (GWAS)
Health aspects
Medicin och hälsovetenskap
meta-analysis
Psychological aspects
Risk factors
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Summary:This study aimed to verify noteworthy findings between genetic risk factors and autism spectrum disorder (ASD) by employing the false positive report probability (FPRP) and the Bayesian false-discovery probability (BFDP). PubMed and the Genome-Wide Association Studies (GWAS) catalog were searched from inception to 1 August, 2019. We included meta-analyses on genetic factors of ASD of any study design. Overall, twenty-seven meta-analyses articles from literature searches, and four manually added articles from the GWAS catalog were re-analyzed. This showed that five of 31 comparisons for meta-analyses of observational studies, 40 out of 203 comparisons for the GWAS meta-analyses, and 18 out of 20 comparisons for the GWAS catalog, respectively, had noteworthy estimations under both Bayesian approaches. In this study, we found noteworthy genetic comparisons highly related to an increased risk of ASD. Multiple genetic comparisons were shown to be associated with ASD risk; however, genuine associations should be carefully verified and understood.
ISSN:2076-3425
2076-3425
DOI:10.3390/brainsci10100692