Local treatment in the setting of de novo metastatic rectal cancer: reappraisal of prognostic factors

This retrospective study was conducted to: (1) provide more modern data on real-life local management of metastatic rectal cancer; (2) compare therapeutic strategies; and (3) identify prognostic factors of local failure, overall survival and progression-free survival. Data about efficacy and acute t...

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Published in:Swiss medical weekly 2021-12, Vol.151 (4950), p.w30034-w30034
Main Authors: Vial, Nicolas, Langrand-Escure, Julien, Diao, Peng, Garcia, Max-Adrien, Jmour, Omar, Ben Mrad, Majed, Guy, Jean-Baptiste, Abid, Wiem, Sotton, Sandrine, Espenel, Sophie, Guillaume, Elodie, Rehailia-Blanchard, Amel, Pigné, Grégoire, Trone, Jane-Chloe, Rancoule, Chloe, Kaczmarek, David, Muron, Thierry, Le Roy, Bertrand, Phelip, Jean-Marc, Vallard, Alexis, Magné, Nicolas
Format: Article
Language:English
Subjects:
Antineoplastic Combined Chemotherapy Protocols - therapeutic use
Digestive System Surgical Procedures
Humans
Neoplasm Recurrence, Local - drug therapy
Neoplasm Staging
Prognosis
Rectal Neoplasms - therapy
Retrospective Studies
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Summary:This retrospective study was conducted to: (1) provide more modern data on real-life local management of metastatic rectal cancer; (2) compare therapeutic strategies; and (3) identify prognostic factors of local failure, overall survival and progression-free survival. Data about efficacy and acute toxicity were collected. Patients were diagnosed with metastatic rectal cancer between 2004 and 2015, and were treated at least with radiotherapy. Local failure, overall survival and progression-free survival were correlated with patient, tumour and treatment characteristics using univariate and multivariate analyses. Data of 148 consecutive patients with metastatic rectal cancer were analysed. Median follow-up was 19 months. Median overall survival was 16 months. All patients received local radiotherapy, with a median equivalent 2 Gy per fraction dose of 47.7 Gy. Rectal surgery was performed in 97 patients (65.6%). The majority of patients (86/97, 88.7%) received pre-operative chemoradiation. In multivariate analysis, rectal surgery was found to be the only independent predictor of increased overall survival (24.6 vs 7.1 months, p
ISSN:1424-3997
1424-3997
DOI:10.4414/SMW.2021.w30034