An Electrochemical Sensor for Sulfadiazine Determination Based on a Copper Nanoparticles/Molecularly Imprinted Overoxidized Polypyrrole Composite

• Published in: Sensors (Basel, Switzerland) Switzerland), 2023-01, Vol.23 (3), p.1270
• Main Authors: Elamin, Manahil Babiker, Ali, Shazalia Mahmoud Ahmed, Essousi, Houda, Chrouda, Amani, Alhaidari, Laila M, Jaffrezic-Renault, Nicole, Barhoumi, Houcine
• Format: Article
• Language: English
• Subjects: Analytical chemistry; Animals; Antiinfectives and antibacterials; Carbon; Chemical Sciences; Chemical sensors; Copper - chemistry; copper nanoparticles; differential pulse voltammetry; Drug resistance in microorganisms; Electric properties; Electrical conduction; Electrochemical Techniques; Electrodes; Environmental Engineering; Environmental Sciences; Imprinted polymers; Laws, regulations and rules; Limit of Detection; Molecular Imprinting; molecularly imprinted polymer; Nanocomposites; Nanomaterials; Nanoparticles; Nanoparticles - chemistry; overoxidized polypyrrole; Physiological aspects; Polymer films; Polymers; Polymers - chemistry; Pyrroles - chemistry; Reagents; Reproducibility of Results; Sensors; Sulfadiazine; Voltammetry; Zinc oxides
• ISSN: 1424-8220; 1424-8220
• DOI: 10.3390/s23031270

To protect consumers from risks related to overexposure to sulfadiazine, total residues of this antibacterial agent in animal-origin foodstuffs not exceed international regulations. To this end, a new electrochemical sensor based on a molecularly imprinted polymer nanocomposite using overoxidized polypyrrole and copper nanoparticles for the detection of sulfadiazine is elaborated. After optimization of the preparation of the electrochemical sensors, their differential pulse voltammetric signal exhibits an excellent stability and reproducibility at 1.05 V, with a large linear range between 10 and 10 mol L and a low detection limit of 3.1 × 10 mol L . The produced sulfadiazine sensor was successfully tested in real milk samples. The combination of the properties of the electrical conduction of copper nanoparticles with the properties of the preconcentration of the molecularly imprinted overoxidized polypyrrole allows for the highly sensitive detection of sulfadiazine, even in real milk samples. This strategy is new and leads to the lowest detection limit yet achieved, compared to those of the previously published sulfadiazine electrochemical sensors.