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Two cases of steroid dementia showing partial recovery during 2‐year follow‐up
Background Steroid dementia has been reported since the 1970s. In the current super‐aged society, it increasingly receives attention because of the growing number of elderly people that are medicated with steroids for systemic rheumatic disease. Case Presentation We report two cases of steroid demen...
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| Published in: | PCN reports 2022-12, Vol.1 (4), p.e49-n/a |
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| container_issue | 4 |
| container_start_page | e49 |
| container_title | PCN reports |
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| creator | Ikeda, Natsuko Yamada, Shinichi Yamamoto, Masahiro Tanaka, Katsunori Fujii, Takao Tsuji, Tomikimi Kimoto, Sohei Takahashi, Shun |
| description | Background
Steroid dementia has been reported since the 1970s. In the current super‐aged society, it increasingly receives attention because of the growing number of elderly people that are medicated with steroids for systemic rheumatic disease.
Case Presentation
We report two cases of steroid dementia that were diagnosed as a result of careful observation of clinical symptoms and biological examination, including nuclear medicine tests. Cognitive and daily living functions were partially recovered in both cases after decrease or discontinuance of steroid medication in 2‐year follow‐up, but their daily living function could not be totally restored to premorbid level.
Conclusion
Cognitive dysfunction caused by steroids is suggested by these cases, although definitive diagnosis in these cases is not possible. It was partially reversible over the course of a few years, but some functional loss remains. Cognitive function should be assessed appropriately before, during, and after steroid treatment. Detailed differential diagnosis of neurodegenerative disorders and longitudinal follow‐up is required when cognitive dysfunction is observed after initiation of steroid therapy. |
| doi_str_mv | 10.1002/pcn5.49 |
| format | article |
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Steroid dementia has been reported since the 1970s. In the current super‐aged society, it increasingly receives attention because of the growing number of elderly people that are medicated with steroids for systemic rheumatic disease.
Case Presentation
We report two cases of steroid dementia that were diagnosed as a result of careful observation of clinical symptoms and biological examination, including nuclear medicine tests. Cognitive and daily living functions were partially recovered in both cases after decrease or discontinuance of steroid medication in 2‐year follow‐up, but their daily living function could not be totally restored to premorbid level.
Conclusion
Cognitive dysfunction caused by steroids is suggested by these cases, although definitive diagnosis in these cases is not possible. It was partially reversible over the course of a few years, but some functional loss remains. Cognitive function should be assessed appropriately before, during, and after steroid treatment. Detailed differential diagnosis of neurodegenerative disorders and longitudinal follow‐up is required when cognitive dysfunction is observed after initiation of steroid therapy.</description><identifier>ISSN: 2769-2558</identifier><identifier>EISSN: 2769-2558</identifier><identifier>DOI: 10.1002/pcn5.49</identifier><identifier>PMID: 38868656</identifier><language>eng</language><publisher>Australia: John Wiley & Sons, Inc</publisher><subject>Alzheimer's disease ; Angina pectoris ; Atrophy ; Case Report ; Case Reports ; cognition ; Cognitive ability ; Delirium ; Dementia ; elderly ; Electroencephalography ; Hospitals ; Magnetic resonance imaging ; Memory ; Nuclear medicine ; Older people ; Patients ; Pneumonia ; recovery ; Scintigraphy ; steroid ; Steroids ; Thyroid gland</subject><ispartof>PCN reports, 2022-12, Vol.1 (4), p.e49-n/a</ispartof><rights>2022 The Authors. published by John Wiley & Sons Australia, Ltd on behalf of Japanese Society of Psychiatry and Neurology.</rights><rights>2022 The Authors. Psychiatry and Clinical Neurosciences Reports published by John Wiley & Sons Australia, Ltd on behalf of Japanese Society of Psychiatry and Neurology.</rights><rights>2022. This work is published under http://creativecommons.org/licenses/by-nc-nd/4.0/ (the "License"). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5249-a55d46135030896ded32ef7e4ab63d660b3024bbbae656e7e8739f8294e86fcb3</citedby><cites>FETCH-LOGICAL-c5249-a55d46135030896ded32ef7e4ab63d660b3024bbbae656e7e8739f8294e86fcb3</cites><orcidid>0000-0002-9049-4694 ; 0000-0001-8626-2981</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC11114292/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/3090892374?pq-origsite=primo$$EHTML$$P50$$Gproquest$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,11562,25753,27924,27925,37012,37013,44590,46052,46476,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38868656$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ikeda, Natsuko</creatorcontrib><creatorcontrib>Yamada, Shinichi</creatorcontrib><creatorcontrib>Yamamoto, Masahiro</creatorcontrib><creatorcontrib>Tanaka, Katsunori</creatorcontrib><creatorcontrib>Fujii, Takao</creatorcontrib><creatorcontrib>Tsuji, Tomikimi</creatorcontrib><creatorcontrib>Kimoto, Sohei</creatorcontrib><creatorcontrib>Takahashi, Shun</creatorcontrib><title>Two cases of steroid dementia showing partial recovery during 2‐year follow‐up</title><title>PCN reports</title><addtitle>PCN Rep</addtitle><description>Background
Steroid dementia has been reported since the 1970s. In the current super‐aged society, it increasingly receives attention because of the growing number of elderly people that are medicated with steroids for systemic rheumatic disease.
Case Presentation
We report two cases of steroid dementia that were diagnosed as a result of careful observation of clinical symptoms and biological examination, including nuclear medicine tests. Cognitive and daily living functions were partially recovered in both cases after decrease or discontinuance of steroid medication in 2‐year follow‐up, but their daily living function could not be totally restored to premorbid level.
Conclusion
Cognitive dysfunction caused by steroids is suggested by these cases, although definitive diagnosis in these cases is not possible. It was partially reversible over the course of a few years, but some functional loss remains. Cognitive function should be assessed appropriately before, during, and after steroid treatment. Detailed differential diagnosis of neurodegenerative disorders and longitudinal follow‐up is required when cognitive dysfunction is observed after initiation of steroid therapy.</description><subject>Alzheimer's disease</subject><subject>Angina pectoris</subject><subject>Atrophy</subject><subject>Case Report</subject><subject>Case Reports</subject><subject>cognition</subject><subject>Cognitive ability</subject><subject>Delirium</subject><subject>Dementia</subject><subject>elderly</subject><subject>Electroencephalography</subject><subject>Hospitals</subject><subject>Magnetic resonance imaging</subject><subject>Memory</subject><subject>Nuclear medicine</subject><subject>Older people</subject><subject>Patients</subject><subject>Pneumonia</subject><subject>recovery</subject><subject>Scintigraphy</subject><subject>steroid</subject><subject>Steroids</subject><subject>Thyroid gland</subject><issn>2769-2558</issn><issn>2769-2558</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>24P</sourceid><sourceid>PIMPY</sourceid><sourceid>DOA</sourceid><recordid>eNp1kd1qFDEUxwdRbKnFN5ABLxRkaybfuRJZ_CgUFanXIR8n21mykzHZ6bJ3PoLP6JOYcWtpBXOTnJMfP_7JaZqnHTrrEMKvRzewM6oeNMdYcLXAjMmHd85HzWkpa1RJKTiX3ePmiEjJJWf8uPl6uUutMwVKm0JbtpBT71sPGxi2vWnLVdr1w6odTa5lbDO4dA153_opz33868fPPZjchhRj2tVqGp80j4KJBU5v9pPm2_t3l8uPi4vPH86Xby8WjmGqFoYxT3lHGCJIKu7BEwxBADWWE885sgRhaq01UJOCACmIChIrCpIHZ8lJc37w-mTWesz9xuS9TqbXfxopr_Sc2kXQ1nNFjAsKi0Bdp6xlyiIvHOOuM4ZV15uDa5zsBryrr88m3pPevxn6K71K17qri2KFq-HljSGn7xOUrd70xUGMZoA0FU0QF6rCckaf_4Ou05SH-leVUvUzMBG0Ui8OlMuplAzhNk2H9Dx3Pc9dU1XJZ3fD33J_p1yBVwdg10fY_8-jvyw_sar7DZRxuIo</recordid><startdate>202212</startdate><enddate>202212</enddate><creator>Ikeda, Natsuko</creator><creator>Yamada, Shinichi</creator><creator>Yamamoto, Masahiro</creator><creator>Tanaka, Katsunori</creator><creator>Fujii, Takao</creator><creator>Tsuji, Tomikimi</creator><creator>Kimoto, Sohei</creator><creator>Takahashi, Shun</creator><general>John Wiley & Sons, Inc</general><general>John Wiley and Sons Inc</general><general>Wiley</general><scope>24P</scope><scope>WIN</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope><orcidid>https://orcid.org/0000-0002-9049-4694</orcidid><orcidid>https://orcid.org/0000-0001-8626-2981</orcidid></search><sort><creationdate>202212</creationdate><title>Two cases of steroid dementia showing partial recovery during 2‐year follow‐up</title><author>Ikeda, Natsuko ; Yamada, Shinichi ; Yamamoto, Masahiro ; Tanaka, Katsunori ; Fujii, Takao ; Tsuji, Tomikimi ; Kimoto, Sohei ; Takahashi, Shun</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5249-a55d46135030896ded32ef7e4ab63d660b3024bbbae656e7e8739f8294e86fcb3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Alzheimer's disease</topic><topic>Angina pectoris</topic><topic>Atrophy</topic><topic>Case Report</topic><topic>Case Reports</topic><topic>cognition</topic><topic>Cognitive ability</topic><topic>Delirium</topic><topic>Dementia</topic><topic>elderly</topic><topic>Electroencephalography</topic><topic>Hospitals</topic><topic>Magnetic resonance imaging</topic><topic>Memory</topic><topic>Nuclear medicine</topic><topic>Older people</topic><topic>Patients</topic><topic>Pneumonia</topic><topic>recovery</topic><topic>Scintigraphy</topic><topic>steroid</topic><topic>Steroids</topic><topic>Thyroid gland</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ikeda, Natsuko</creatorcontrib><creatorcontrib>Yamada, Shinichi</creatorcontrib><creatorcontrib>Yamamoto, Masahiro</creatorcontrib><creatorcontrib>Tanaka, Katsunori</creatorcontrib><creatorcontrib>Fujii, Takao</creatorcontrib><creatorcontrib>Tsuji, Tomikimi</creatorcontrib><creatorcontrib>Kimoto, Sohei</creatorcontrib><creatorcontrib>Takahashi, Shun</creatorcontrib><collection>Wiley Open Access Journals</collection><collection>Wiley Online Library Free Content</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest One Psychology</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>Directory of Open Access Journals</collection><jtitle>PCN reports</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ikeda, Natsuko</au><au>Yamada, Shinichi</au><au>Yamamoto, Masahiro</au><au>Tanaka, Katsunori</au><au>Fujii, Takao</au><au>Tsuji, Tomikimi</au><au>Kimoto, Sohei</au><au>Takahashi, Shun</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Two cases of steroid dementia showing partial recovery during 2‐year follow‐up</atitle><jtitle>PCN reports</jtitle><addtitle>PCN Rep</addtitle><date>2022-12</date><risdate>2022</risdate><volume>1</volume><issue>4</issue><spage>e49</spage><epage>n/a</epage><pages>e49-n/a</pages><issn>2769-2558</issn><eissn>2769-2558</eissn><abstract>Background
Steroid dementia has been reported since the 1970s. In the current super‐aged society, it increasingly receives attention because of the growing number of elderly people that are medicated with steroids for systemic rheumatic disease.
Case Presentation
We report two cases of steroid dementia that were diagnosed as a result of careful observation of clinical symptoms and biological examination, including nuclear medicine tests. Cognitive and daily living functions were partially recovered in both cases after decrease or discontinuance of steroid medication in 2‐year follow‐up, but their daily living function could not be totally restored to premorbid level.
Conclusion
Cognitive dysfunction caused by steroids is suggested by these cases, although definitive diagnosis in these cases is not possible. It was partially reversible over the course of a few years, but some functional loss remains. Cognitive function should be assessed appropriately before, during, and after steroid treatment. Detailed differential diagnosis of neurodegenerative disorders and longitudinal follow‐up is required when cognitive dysfunction is observed after initiation of steroid therapy.</abstract><cop>Australia</cop><pub>John Wiley & Sons, Inc</pub><pmid>38868656</pmid><doi>10.1002/pcn5.49</doi><tpages>5</tpages><orcidid>https://orcid.org/0000-0002-9049-4694</orcidid><orcidid>https://orcid.org/0000-0001-8626-2981</orcidid><oa>free_for_read</oa></addata></record> |
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| source | PubMed (Medline); Publicly Available Content Database; Wiley Open Access Journals |
| subjects | Alzheimer's disease Angina pectoris Atrophy Case Report Case Reports cognition Cognitive ability Delirium Dementia elderly Electroencephalography Hospitals Magnetic resonance imaging Memory Nuclear medicine Older people Patients Pneumonia recovery Scintigraphy steroid Steroids Thyroid gland |
| title | Two cases of steroid dementia showing partial recovery during 2‐year follow‐up |
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