Hepatitis B infection is associated with periodontitis: the national health and nutrition examination survey (2009-2014)

• Published in: BMC oral health 2024-07, Vol.24 (1), p.815-8, Article 815
• Main Authors: Chen, XianRun, Song, Jukun, Sun, JiangLing, Zhang, JiQin, Chen, XingJin, Zeng, ChongWen, Hu, JiaXin, Chang, XingTao, Jin, FuQian, Luo, SiYang, Chen, Zhu, Luo, Yi
• Format: Article
• Language: English
• Subjects: Adult; Antibodies; Bacteria; Body mass index; Chronic infection; Creatinine; Cross-Sectional Studies; Development and progression; Diabetes mellitus; Diagnosis; Disease control; Female; Gum disease; Health aspects; Health surveys; Hepatitis B; Hepatitis B - complications; Hepatitis B - epidemiology; Hepatitis B infection; Humans; Hypertension; Infection; Infections; Inflammation; Liver diseases; Male; Medical laboratories; Medical research; Middle Aged; NHANES; Nutrition; Nutrition Surveys; Oral hygiene; Periodontitis; Periodontitis - complications; Periodontitis - epidemiology; Prevalence; Risk Factors; Surveys; Teeth; United States - epidemiology; Viruses
• ISSN: 1472-6831; 1472-6831
• DOI: 10.1186/s12903-024-04489-y

Current research has been inconclusive regarding whether hepatitis B infection is associated with an increased risk of periodontitis. This study aims to test the null hypothesis that no association exists between hepatitis B infection and an increased risk of periodontitis using the National Health and Nutrition Examination Survey (2009-2014). We performed a cross-sectional study using the National Health and Nutrition Examination Survey (NHANES) database (2009-2014) to assess the rate of the prevalence of periodontitis in patients with and without hepatitis B infection. Participants who had tested for hepatitis B and periodontitis were included. The included participants were divided into no/mild periodontitis and moderate/severe periodontitis groups according to their periodontal status. The association between hepatitis B infection and chronic periodontitis was evaluated by multivariable regression analyses adjusting for age, gender, race/ethnicity, education level, income-to-poverty ratio, smoking, alcohol, BMI, ALT, AST, creatinine, hypertension, and diabetes. A total of 5957 participants were included and divided into two groups: inactive periodontitis group (n = 3444) and active periodontitis group (n = 2513). The results showed that participants with hepatitis B had a higher risk of periodontitis. After adjusting for covariables, adults with hepatitis B infection were 38% more likely to have periodontitis compared to those without hepatitis B infection (95% Confidence Interval [CI]:1.085-1.754). In general, the results suggest that CHB is positively associated with the more severe periodontitis. These results suggest that people with hepatitis B infection should take good periodontal care measures to avoid the occurrence and development of periodontitis.