Levels of soluble cell adhesion molecules in type 2 diabetes mellitus patients with macrovascular complications

• Published in: Journal of international medical research 2020-04, Vol.48 (4), p.300060519893858-300060519893858
• Main Authors: Hegazy, Gehan A, Awan, Zuhier, Hashem, Enayat, Al-Ama, Nabil, Abunaji, Asmaa Basha
• Format: Article
• Language: English
• Subjects: Cardiovascular disease; Cardiovascular Diseases - complications; Cell adhesion & migration; Cell Adhesion Molecules; Cross-Sectional Studies; Diabetes; Diabetes Mellitus, Type 2 - complications; E-Selectin - blood; Humans; Intercellular Adhesion Molecule-1 - blood; Retrospective Clinical Research Report; Vascular Cell Adhesion Molecule-1 - blood
• ISSN: 0300-0605; 1473-2300
• DOI: 10.1177/0300060519893858

Objective Type 2 diabetes mellitus (T2DM) is a main risk factor for development of cardiovascular diseases (CVDs) and endothelial dysfunction. This study aimed to investigate serum levels of soluble vascular cell adhesion molecule 1 (sVCAM-1), intercellular adhesion molecule 1 (sICAM-1), and endothelium selectin (sE-selectin) in T2DM patients with macrovascular complications. Methods A cross-sectional study of 21 controls, 30 T2DM patients without CVDs, and 30 T2DM patients with CVDs was conducted. Serum levels of soluble adhesion molecules including sVCAM-1, sICAM-1, and sE-selectin were determined using ELISA. Results Serum levels of sVCAM-1, sICAM-1, and sE-selectin were higher in T2DM patients than in controls. Levels of serum sVCAM-1 were higher in T2DM patients with CVDs compared with T2DM patients without CVDs. In T2DM patients with CVDs, significant positive associations were observed between sVCAM-1, sICAM-1, and sE-selectin levels (r = 0.575, p = 0.001 and r = 0.378, p = 0.040). Conclusions Circulating levels of soluble adhesion molecules were elevated in T2DM patients, regardless of whether the patients had cardiovascular complications. Only sVCAM-1 was considered a useful marker for the prediction of CVDs in T2DM patients.