Magnetic resonance spectroscopy in the prediction of early conversion from amnestic mild cognitive impairment to dementia: a prospective cohort study

BackgroundMild cognitive impairment (MCI) of an amnestic type is a common condition in older people and highly predictive of Alzheimer's disease (AD). To date, there is no clear consensus regarding the best antecedent biomarker to predict early conversion to AD.ObjectiveThe aim of the study is...

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Bibliographic Details
Published in:BMJ open 2011-01, Vol.1 (1), p.e000007-e000007
Main Authors: Modrego, Pedro J, Fayed, Nicolas, Sarasa, Manuel
Format: Article
Language:English
Subjects:
adult neurology
Alzheimer's disease
Biomarkers
Dementia
Longitudinal studies
Magnetic resonance imaging
magnetic resonance spectroscopy
Medical prognosis
Mild cognitive impairment
Neurology
Spectrum analysis
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Summary:BackgroundMild cognitive impairment (MCI) of an amnestic type is a common condition in older people and highly predictive of Alzheimer's disease (AD). To date, there is no clear consensus regarding the best antecedent biomarker to predict early conversion to AD.ObjectiveThe aim of the study is to demonstrate that 1H magnetic resonance spectroscopy (MRS) of the brain in MCI patients may predict early conversion to dementia within the 2-year period after baseline assessment.MethodsA cohort of patients fulfilling the criteria of amnestic MCI were enrolled consecutively. At baseline the patients underwent neuropsychological examination, standard blood tests and APOE genotype. 1H-MRS (1.5 T) of the brain was carried out by exploring two areas: the posteromedial bilateral parietal lobe and left medial occipital lobe. The patients were followed up to detect conversion to probable AD according to the National Institute of Neurological and Communicative Disorders and Stroke and the Alzheimer's Disease and Related Disorders Association group criteria.ResultsAfter a 2-year follow-up, 27 (38%) patients converted to AD. The mean N-acetyl-aspartate/creatine (NAA/Cr) ratio in the posteromedial bilateral parietal cortex was 1.38 in converters versus 1.49 in non-converters (p
ISSN:2044-6055
2044-6055
DOI:10.1136/bmjopen-2010-000007