Toward Long-Term Implantable Glucose Biosensors for Clinical Use

Continuous glucose monitoring (CGM) sensors have led a paradigm shift to painless, continuous, zero-finger pricking measurement in blood glucose monitoring. Recent electrochemical CGM sensors have reached two-week lifespans and no calibration with clinically acceptable accuracy. The system with the...

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Bibliographic Details
Published in:Applied sciences 2019-05, Vol.9 (10), p.2158
Main Authors: Heo, Yun Jung, Kim, Seong-Hyok
Format: Article
Language:English
Subjects:
Accuracy
Automation
Biocompatibility
Biosensors
Blood
Blood levels
boronic acid
Calibration
Cardiovascular diseases
Complications
continuous glucose monitoring
Coronary artery disease
Diabetes
Diabetes mellitus
Diabetic neuropathy
Diabetic retinopathy
Error analysis
Federal regulation
Glucose
Glucose monitoring
glucose oxidase
Heart diseases
Hyperglycemia
Hypoglycemia
Insulin
Monitoring systems
Reading
Renal failure
Retinopathy
Sensors
subcutaneous sensor
Surgical implants
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Summary:Continuous glucose monitoring (CGM) sensors have led a paradigm shift to painless, continuous, zero-finger pricking measurement in blood glucose monitoring. Recent electrochemical CGM sensors have reached two-week lifespans and no calibration with clinically acceptable accuracy. The system with the recent CGM sensors is identified as an “integrated glucose monitoring system,” which can replace finger-pricking glucose-testing for diabetes treatment decisions. Although such innovation has brought CGM technology closer to realizing the artificial pancreas, discomfort and infection problems have arisen from short lifespans and open wounds. A fully implantable sensor with a longer-term lifespan (90 days) is considered as an alternative CGM sensor with high comfort and low running cost. However, it still has barriers, including surgery for applying and replacing and frequent calibration. If technical refinement is conducted (e.g., stability and reproducibility of sensor fabrication), fully implantable, long-term CGM sensors can open the new era of continuous glucose monitoring.
ISSN:2076-3417
2076-3417
DOI:10.3390/app9102158