Promising Strategies to Reduce the SARS-CoV-2 Amyloid Deposition in the Brain and Prevent COVID-19-Exacerbated Dementia and Alzheimer's Disease

The COVID-19 pandemic, caused by infection with the SARS-CoV-2 virus, is associated with cognitive impairment and Alzheimer's disease (AD) progression. Once it enters the brain, the SARS-CoV-2 virus stimulates accumulation of amyloids in the brain that are highly toxic to neural cells. These am...

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Published in:Pharmaceuticals (Basel, Switzerland) Switzerland), 2024-06, Vol.17 (6), p.788
Main Authors: Navolokin, Nikita, Adushkina, Viktoria, Zlatogorskaya, Daria, Telnova, Valeria, Evsiukova, Arina, Vodovozova, Elena, Eroshova, Anna, Dosadina, Elina, Diduk, Sergey, Semyachkina-Glushkovskaya, Oxana
Format: Article
Language:English
Subjects:
Alzheimer’s disease
COVID-19
Dementia
Disease
Hypoxia
Immunotherapy
Infections
Memory
meningeal lymphatics
photobiomodulation
plasmalogens
Proteins
Review
SARS-CoV-2 amyloid
Severe acute respiratory syndrome coronavirus 2
Toxicity
Viruses
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Summary:The COVID-19 pandemic, caused by infection with the SARS-CoV-2 virus, is associated with cognitive impairment and Alzheimer's disease (AD) progression. Once it enters the brain, the SARS-CoV-2 virus stimulates accumulation of amyloids in the brain that are highly toxic to neural cells. These amyloids may trigger neurological symptoms in COVID-19. The meningeal lymphatic vessels (MLVs) play an important role in removal of toxins and mediate viral drainage from the brain. MLVs are considered a promising target to prevent COVID-19-exacerbated dementia. However, there are limited methods for augmentation of MLV function. This review highlights new discoveries in the field of COVID-19-mediated amyloid accumulation in the brain associated with the neurological symptoms and the development of promising strategies to stimulate clearance of amyloids from the brain through lymphatic and other pathways. These strategies are based on innovative methods of treating brain dysfunction induced by COVID-19 infection, including the use of photobiomodulation, plasmalogens, and medicinal herbs, which offer hope for addressing the challenges posed by the SARS-CoV-2 virus.
ISSN:1424-8247
1424-8247
DOI:10.3390/ph17060788