The anti-diabetic effects of betanin in streptozotocin-induced diabetic rats through modulating AMPK/SIRT1/NF-κB signaling pathway

Background In the last few years, the effects of bioactive food components have received much attention because of their beneficial effects including decreasing inflammation, scavenging free radicals, and regulating cell signaling pathways. Betanin as a potent antioxidant has been previously reporte...

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Published in:Nutrition & metabolism 2021-10, Vol.18 (1), p.1-92, Article 92
Main Authors: Abedimanesh, Nasim, Asghari, Somayyeh, Mohammadnejad, Kosar, Daneshvar, Zahra, Rahmani, Soudeh, Shokoohi, Samaneh, Farzaneh, Amir Hasan, Hosseini, Seyed Hojjat, Jafari Anarkooli, Iraj, Noubarani, Maryam, Andalib, Sina, Eskandari, Mohammad Reza, Motlagh, Behrooz
Format: Article
Language:English
Subjects:
Adenosine kinase
AMP
AMPK
Antidiabetics
Antioxidants
Betanin
Bioassays
Blood glucose
Cell signaling
Cholesterol
Diabetes
Diabetes mellitus
Enzymes
Free radicals
Gene expression
Glucose
Glucose tolerance
High density lipoprotein
Homeostasis
Inflammation
Insulin
Insulin resistance
Kinases
Laboratories
Lipids
Liver
Metabolism
Molecular modelling
NF-κB
NF-κB protein
Oxidative stress
Pancreas
Protein kinase
Proteins
Rat
Rodents
Signal transduction
SIRT1
SIRT1 protein
Streptozocin
Veins & arteries
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Summary:Background In the last few years, the effects of bioactive food components have received much attention because of their beneficial effects including decreasing inflammation, scavenging free radicals, and regulating cell signaling pathways. Betanin as a potent antioxidant has been previously reported to exhibit anti diabetic effects. The present study aimed to evaluate the effects of betanin on glycemic control, lipid profile, hepatic function tests, as well as the gene expression levels of 5′ adenosine monophosphate‑activated protein kinase (AMPK), sirtuin-1 (SIRT1), and nuclear factor kappa B (NF‑κB) in streptozocin (STZ) induced diabetic rats. Methods Diabetes was induced in male Sprague–Dawley rats by intraperitoneal administration of STZ. Different doses of betanin (10, 20 and 40 mg/kg.b.w) was administered to diabetic rats for 28 days. Fasting blood glucose and serum insulin were measured. The histopathology of liver and pancreas tissue evaluated. Real-time PCR was performed to assess gene expression levels. Results Treatment of diabetic rats with betanin (10 and 20 mg/kg.b.w) reduced FBG levels compared to the control diabetic rats (P 
ISSN:1743-7075
1743-7075
DOI:10.1186/s12986-021-00621-9