An efficient synthesis of furan-3(2 H )-imine scaffold from alkynones

A novel efficient method to generate spiro furan-3(2 H )-imine derivatives is established by the reaction between the α , β -unsaturated ketones and aniline derivatives. The reaction involves 1,4- addition of aniline followed by the subsequent intramolecular cyclization mediated by tertiary alcohol...

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Bibliographic Details
Published in:Royal Society open science 2021-11, Vol.8 (11), p.211145-211145
Main Authors: Rasras, Anas J., Shehadi, Ihsan A., Younes, Eyad A., Jaradat, Da'san M. M., AlQawasmeh, Raed A.
Format: Article
Language:English
Subjects:
alkynones
authors
Chemistry
efficient
furan-3(2H)-imine
scaffold
synthesis
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Summary:A novel efficient method to generate spiro furan-3(2 H )-imine derivatives is established by the reaction between the α , β -unsaturated ketones and aniline derivatives. The reaction involves 1,4- addition of aniline followed by the subsequent intramolecular cyclization mediated by tertiary alcohol to produce the furan-3(2 H )-imine. All the synthesized compounds are characterized using nuclear magnetic resonance and high-resolution mass spectrometry (HRMS).
ISSN:2054-5703
2054-5703
DOI:10.1098/rsos.211145