MBL2 Genotypes and Their Associations with MBL Levels and NICU Morbidity in a Cohort of Greek Neonates

The objective of this study was to assess the frequency of MBL2 genotypes and their associations with MBL levels and various morbidities of a neonatal intensive care unit (NICU). One hundred and thirty-four (134) NICU (83 term and 51 preterm) and 150 healthy neonates were enrolled in the study. MBL2...

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Bibliographic Details
Published in:Journal of immunology research 2015-01, Vol.2015 (2015), p.1-10
Main Authors: Germenis, Anastasios E., Sokou, Rozeta, Konstantinidi, Katerina, Kompoti, Maria, Sevdali, Eirini, Gounaris, Antonios, Speletas, Matthaios, Tsitsami, Elena
Format: Article
Language:English
Subjects:
C-Reactive Protein - metabolism
Cystic fibrosis
Deoxyribonucleic acid
Disease
DNA
Family medical history
Female
Genes
Greece
Haplotypes - genetics
Health sciences
Hospitals
Humans
Immune system
Immunology
Infant, Newborn
Infant, Premature
Infections
Intensive care
Intensive Care, Neonatal
Lungs
Male
Mannose-Binding Lectin - blood
Mannose-Binding Lectin - genetics
Mannose-Binding Lectin - metabolism
Microorganisms
Morbidity
Polymorphism, Single Nucleotide
Premature Birth - mortality
Promoter Regions, Genetic - genetics
Proteins
Respiratory distress syndrome
Respiratory Distress Syndrome, Newborn - genetics
Respiratory Distress Syndrome, Newborn - mortality
Studies
Surfactants
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Summary:The objective of this study was to assess the frequency of MBL2 genotypes and their associations with MBL levels and various morbidities of a neonatal intensive care unit (NICU). One hundred and thirty-four (134) NICU (83 term and 51 preterm) and 150 healthy neonates were enrolled in the study. MBL2 genotype and MBL serum levels at birth were determined prospectively by PCR-RFLP-sequencing and enzyme-linked immunosorbent assay, respectively. NICU neonates displayed significantly lower MBL serum levels compared to healthy ones. MBL deficiency, defined as the low MBL2 expression group (XA/O and O/O), was significantly associated with an increased risk of respiratory morbidity, especially transient tachypnea of the newborn and respiratory distress syndrome (RDS). Moreover, an increase of 100 ng/mL of serum MBL levels decreases by 5% the risk of total respiratory morbidity and by 7% the risk of RDS, after correction for prematurity and sex and regardless of the presence of infections. Our study further supports the notion that neonates with MBL deficiency and low MBL serum levels at birth may be at higher risk of developing severe respiratory complications.
ISSN:2314-8861
2314-7156
DOI:10.1155/2015/478412