Hypertrophic olivary degeneration concomitant with bilateral middle cerebellar peduncles Wallerian degeneration following unilateral pontine infarction

Wallerian degeneration (WD) can occur in different projecting systems, such as corticospinal tract, dentate-rubro-olivary pathway, and corticopontocerebellar tract. However, the co-occurrence of hypertrophic olivary degeneration (HOD) and middle cerebellar peduncles (MCPs) degeneration secondary to...

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Bibliographic Details
Published in:BMC neurology 2020-11, Vol.20 (1), p.409-409, Article 409
Main Authors: Bao, Bing, Wu, Xiangbin, Xia, Zhongbin, Shen, Yaoyao
Format: Article
Language:English
Subjects:
Aged
Brain infarction
Brain Stem Infarctions - pathology
Case Report
Case studies
Cerebellum
Cerebral infarction
Diagnosis
Funding
Hemorrhage
Humans
Hypertrophic olivary degeneration
Hypertrophy - pathology
Ischemia
Ischemic Stroke - pathology
Magnetic resonance imaging
Magnetic Resonance Imaging - methods
Male
Medulla oblongata
Metabolism
Middle Cerebellar Peduncle - pathology
Middle cerebellar peduncles
MRI
Neurodegeneration
Neurodegenerative diseases
Neuroimaging
Olivary Nucleus - pathology
Paresis - etiology
Pons
Pons - pathology
Pyramidal tracts
Pyramidal Tracts - pathology
Rehabilitation
Spinal cord
Stroke
Surgery
Thrombolysis
Wallerian degeneration
Wallerian Degeneration - pathology
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Summary:Wallerian degeneration (WD) can occur in different projecting systems, such as corticospinal tract, dentate-rubro-olivary pathway, and corticopontocerebellar tract. However, the co-occurrence of hypertrophic olivary degeneration (HOD) and middle cerebellar peduncles (MCPs) degeneration secondary to unilateral pontine infarction in a single patient is extremely rare. A 71-year-old man presented with acute onset of dizzness, slurred speech, and right-sided weakness. On the next day, his previous neurologic deficits deteriorated. Brain magnetic resonance imaging (MRI) revealed acute ischemic stroke of the left pons. After treatment with thrombolysis, antiplatelets, and rehabilitation training, his speaking and motor function improved moderately. At the 3-month follow-up, the MRI showed hyperintensity in the left medulla oblongata and bilateral MCPs on T2-weighted and FLAIR images, suggesting HOD as well as MCPs degeneration. It is of great importance for us to know the anatomic knowledge of dentate-rubro-olivary and corticopontocerebellar pathways.
ISSN:1471-2377
1471-2377
DOI:10.1186/s12883-020-01984-x