Prognostic Impact of Cardiac Diastolic Function and Coronary Microvascular Function on Cardiovascular Death

• Published in: Journal of the American Heart Association 2023-02, Vol.12 (3), p.e027690-e027690
• Main Authors: Hong, David, Lee, Seung Hun, Shin, Doosup, Choi, Ki Hong, Kim, Hyun Kuk, Ha, Sang Jin, Joh, Hyun Sung, Park, Taek Kyu, Yang, Jeong Hoon, Song, Young Bin, Hahn, Joo-Yong, Choi, Seung-Hyuk, Gwon, Hyeon-Cheol, Lee, Joo Myung
• Format: Article
• Language: English
• Subjects: cardiac diastolic dysfunction; coronary flow reserve; coronary microvascular dysfunction; Coronary Stenosis - complications; Coronary Stenosis - diagnostic imaging; Coronary Vessels - diagnostic imaging; Fractional Flow Reserve, Myocardial; Heart Diseases; Heart Failure; Humans; index of microcirculatory resistance; Microcirculation; Myocardial Ischemia; Original Research; Prognosis; Stroke Volume; Ventricular Dysfunction, Left - diagnostic imaging; Ventricular Function, Left
• ISSN: 2047-9980; 2047-9980
• DOI: 10.1161/JAHA.122.027690

Background Coronary microvascular dysfunction (CMD) has been considered as a possible cause of cardiac diastolic dysfunction. The current study evaluated the association between cardiac diastolic dysfunction and CMD, and their prognostic implications in patients without significant left ventricular systolic dysfunction and epicardial coronary stenosis. Methods and Results A total of 330 patients without left ventricular systolic dysfunction (ejection fraction ≥50%) and significant epicardial coronary stenosis (fractional flow reserve >0.80) were analyzed. Cardiac diastolic dysfunction was defined by echocardiographic parameters (early diastolic transmitral flow velocity/early diastolic mitral annular velocity, e' velocity, tricuspid regurgitation velocity, and left atrial volume index). Overt CMD was defined as coronary flow reserve