Elsholtzia bodinieri Vaniot Ameliorated Acute Lung Injury by NQO1, BCL2 and PTGS2 In Silico and In Vitro Analyses

Acute lung injury (ALI) is a clinical respiratory disease caused by various factors, which lacks effective pharmacotherapy to reduce the mortality rate. Vaniot is an annual herbaceous plant used as a traditional herbal tea and folk medicine. Here we used bioinformatic databases and software to explo...

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Bibliographic Details
Published in:International journal of molecular sciences 2022-12, Vol.23 (24), p.15651
Main Authors: Sun, Jin, Jiang, Xiaoqian, Chen, Yuxu, Guo, Shancheng, Zhao, Zhiye, Cao, Jianxin, Liu, Yaping, Cheng, Guiguang, Li, Ye, Tian, Lei
Format: Article
Language:English
Subjects:
acute lung injury
Acute Lung Injury - etiology
BCL2
Bioinformatics
Chemical compounds
Coronaviruses
COVID-19
Cyclooxygenase 2 - genetics
Cytokines
Datasets
Disease transmission
Drug therapy
Edema
Elsholtzia
Elsholtzia bodinieri Vaniot
Folk medicine
Food sources
Functional foods & nutraceuticals
Genes
Herbal medicine
Herbal tea
Humans
Inflammation
Inflammation - complications
Injury analysis
Lamiaceae - chemistry
Leukemia
Lungs
Lymphoma
NAD(P)H Dehydrogenase (Quinone) - genetics
NADPH dehydrogenase
NQO1
Oxidative Stress
Pharmacology
Plant Extracts - pharmacology
Prostaglandin endoperoxide synthase
Proto-Oncogene Proteins c-bcl-2 - genetics
PTGS2
Pyroptosis
Quinones
Respiratory diseases
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Summary:Acute lung injury (ALI) is a clinical respiratory disease caused by various factors, which lacks effective pharmacotherapy to reduce the mortality rate. Vaniot is an annual herbaceous plant used as a traditional herbal tea and folk medicine. Here we used bioinformatic databases and software to explore and analyze the potential key genes in ALI regulated by Vaniot, including B cell leukemia/lymphoma 2 ( ), prostaglandin-endoperoxide synthase 2 ( ) and NAD(P)H dehydrogenase, quinone 1 ( ). In an inflammatory cells model, we verified bioinformatics results, and further mechanistic analysis showed that methanol extract of Vaniot (EBE) could alleviate oxidative stress by upregulating the expression of NQO1, suppress pyroptosis by upregulating the expression of BCL2, and attenuate inflammation by downregulating the expression of PTGS2. In sum, our results demonstrated that EBE treatment could alleviate oxidative stress, suppress pyroptosis and attenuate inflammation by regulating NQO1, BCL2 and PTGS2 in a cells model, and Vaniot might be a promising source for functional food or as a therapeutic agent.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms232415651