Oxidative Stress and Neurodevelopmental Outcomes in Rat Offspring with Intrauterine Growth Restriction Induced by Reduced Uterine Perfusion

Intrauterine growth restriction (IUGR) is a major cause of morbidity and mortality and is worldwide associated with delayed neurodevelopment. The exact mechanism involved in delayed neurodevelopment associated with IUGR is still unclear. Reduced uterine perfusion (RUP) is among the main causes of pl...

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Bibliographic Details
Published in:Brain sciences 2021-01, Vol.11 (1), p.78
Main Authors: Rains, Marcelo E, Muncie, Colin B, Pang, Yi, Fan, Lir-Wan, Tien, Lu-Tai, Ojeda, Norma B
Format: Article
Language:English
Subjects:
Abdomen
Animal cognition
Behavior
Birth weight
Cognition
Cognitive ability
intrauterine growth restriction
Lipid peroxidation
Morbidity
motor and cognitive development
Neurodevelopment
Offspring
Oxidative stress
Pattern recognition
Perfusion
Placenta
reduced uterine perfusion
Silver
Surgery
Uterus
Veins & arteries
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Summary:Intrauterine growth restriction (IUGR) is a major cause of morbidity and mortality and is worldwide associated with delayed neurodevelopment. The exact mechanism involved in delayed neurodevelopment associated with IUGR is still unclear. Reduced uterine perfusion (RUP) is among the main causes of placental insufficiency leading to IUGR, which is associated with increases in oxidative stress. This study investigated whether oxidative stress is associated with delayed neurodevelopment in IUGR rat pups. Pregnant rats were exposed to RUP surgery on gestational day 14 to generate IUGR rat offspring. We evaluated offspring's morphometric at birth, and neurodevelopment on postnatal day 21 (PD21) as well as markers of oxidative stress in plasma and brain. Offspring from dams exposed to RUP showed significant ( < 0.05) lower birth weight compared to controls, indicating IUGR. Motor and cognitive deficits, and levels of oxidative stress markers, were significantly ( < 0.05) elevated in IUGR offspring compared to controls. IUGR offspring showed significant ( < 0.05) negative correlations between brain lipid peroxidation and neurocognitive tests (open field and novel object recognition) in comparison with controls. Our findings suggest that neurodevelopmental delay observed in IUGR rat offspring is associated with increased levels of oxidative stress markers.
ISSN:2076-3425
2076-3425
DOI:10.3390/brainsci11010078