Plasma vaspin levels and clinical outcome in incident peritoneal dialysis patients

Vaspin is an adipokine that regulates glucose and lipid metabolism. Plasma vaspin level is increased in chronic kidney disease but decreased in hemodialysis patients. However, plasma vaspin level in peritoneal dialysis (PD) patients, as well as its prognostic role, has not been studied. We recruited...

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Published in:BMC nephrology 2023-07, Vol.24 (1), p.206-206, Article 206
Main Authors: Than, Win Hlaing, Chan, Gordon Chun-Kau, Kwan, Bonnie Ching-Ha, Lai, Ka-Bik, Chan, Ronald Cheong-Kin, Teoh, Jeromy Yuen Chun, Ng, Jack Kit-Chung, Fung, Winston Wing-Shing, Chow, Kai-Ming, Cheng, Phyllis Mei-Shan, Li, Philip Kam-Tao, Szeto, Cheuk-Chun
Format: Article
Language:English
Subjects:
Adipokines
Adipose tissue
Aged
Anthropometry
Atherosclerosis
Body fat
Body mass index
Cardiovascular diseases
Care and treatment
Chronic kidney failure
Clinical outcomes
Continuous ambulatory peritoneal dialysis
Creatinine
Diabetes
Diabetes mellitus
Dialysate
Female
Glucose
Glucose metabolism
Health aspects
Hemodialysis
Humans
Inflammation
Insulin Resistance
Kidney diseases
Kidney transplants
Lipid metabolism
Male
Measurement
Metabolic syndrome
Middle Aged
Mortality
Nephrology
Nutritional status
Obesity
Overweight
Patient outcomes
Patients
Peritoneal Dialysis
Peritoneum
Plasma
Prevention
Renal Dialysis
Renal failure
Risk factors
Serine
Serpins - blood
Spectroscopy
Spectrum analysis
Statistical analysis
Survival
Survival analysis
Variance analysis
Velocity
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container_end_page 206
container_issue 1
container_start_page 206
container_title BMC nephrology
container_volume 24
creator Than, Win Hlaing
Chan, Gordon Chun-Kau
Kwan, Bonnie Ching-Ha
Lai, Ka-Bik
Chan, Ronald Cheong-Kin
Teoh, Jeromy Yuen Chun
Ng, Jack Kit-Chung
Fung, Winston Wing-Shing
Chow, Kai-Ming
Cheng, Phyllis Mei-Shan
Li, Philip Kam-Tao
Szeto, Cheuk-Chun
description Vaspin is an adipokine that regulates glucose and lipid metabolism. Plasma vaspin level is increased in chronic kidney disease but decreased in hemodialysis patients. However, plasma vaspin level in peritoneal dialysis (PD) patients, as well as its prognostic role, has not been studied. We recruited 146 incident PD patients. Their baseline plasma vaspin levels, body anthropometry, the profile of insulin resistance, bioimpedance spectroscopy parameters, dialysis adequacy, and nutritional indices were measured. They were followed for up to 5 years for survival analysis. The average age was 58.4 ± 11.8 years; 96 patients (65.8%) were men, and 90 (61.6%) had diabetes. The median vaspin level was 0.18 ng/dL (interquartile range [IQR] 0.11 to 0.30 ng/dL). Plasma vaspin level did not have a significant correlation with adipose tissue mass or baseline insulin level. However, plasma vaspin level had a modest correlation with the change in insulin resistance, as represented by the HOMA-IR index, in non-diabetic patients (r = -0.358, p = 0.048). Although the plasma vaspin level quartile did not have a significant association with patient survival in the entire cohort, it had a significant interaction with diabetic status (p 
doi_str_mv 10.1186/s12882-023-03259-2
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Plasma vaspin level is increased in chronic kidney disease but decreased in hemodialysis patients. However, plasma vaspin level in peritoneal dialysis (PD) patients, as well as its prognostic role, has not been studied. We recruited 146 incident PD patients. Their baseline plasma vaspin levels, body anthropometry, the profile of insulin resistance, bioimpedance spectroscopy parameters, dialysis adequacy, and nutritional indices were measured. They were followed for up to 5 years for survival analysis. The average age was 58.4 ± 11.8 years; 96 patients (65.8%) were men, and 90 (61.6%) had diabetes. The median vaspin level was 0.18 ng/dL (interquartile range [IQR] 0.11 to 0.30 ng/dL). Plasma vaspin level did not have a significant correlation with adipose tissue mass or baseline insulin level. However, plasma vaspin level had a modest correlation with the change in insulin resistance, as represented by the HOMA-IR index, in non-diabetic patients (r = -0.358, p = 0.048). Although the plasma vaspin level quartile did not have a significant association with patient survival in the entire cohort, it had a significant interaction with diabetic status (p &lt; 0.001). In nondiabetic patients, plasma vaspin level quartile was an independent predictor of patient survival after adjusting for confounding clinical factors (adjusted hazard ratio 2.038, 95% confidence interval 1.191-3.487, p = 0.009), while the result for diabetic patients was not significant. Plasma vaspin level quartile had a significant association with patient survival in non-diabetic PD patients. Baseline plasma vaspin level also had a modest inverse correlation with the subsequent change in the severity of insulin resistance, but the exact biological role of vaspin deserves further studies.</description><identifier>ISSN: 1471-2369</identifier><identifier>EISSN: 1471-2369</identifier><identifier>DOI: 10.1186/s12882-023-03259-2</identifier><identifier>PMID: 37438733</identifier><language>eng</language><publisher>England: BioMed Central Ltd</publisher><subject>Adipokines ; Adipose tissue ; Aged ; Anthropometry ; Atherosclerosis ; Body fat ; Body mass index ; Cardiovascular diseases ; Care and treatment ; Chronic kidney failure ; Clinical outcomes ; Continuous ambulatory peritoneal dialysis ; Creatinine ; Diabetes ; Diabetes mellitus ; Dialysate ; Female ; Glucose ; Glucose metabolism ; Health aspects ; Hemodialysis ; Humans ; Inflammation ; Insulin Resistance ; Kidney diseases ; Kidney transplants ; Lipid metabolism ; Male ; Measurement ; Metabolic syndrome ; Middle Aged ; Mortality ; Nephrology ; Nutritional status ; Obesity ; Overweight ; Patient outcomes ; Patients ; Peritoneal Dialysis ; Peritoneum ; Plasma ; Prevention ; Renal Dialysis ; Renal failure ; Risk factors ; Serine ; Serpins - blood ; Spectroscopy ; Spectrum analysis ; Statistical analysis ; Survival ; Survival analysis ; Variance analysis ; Velocity</subject><ispartof>BMC nephrology, 2023-07, Vol.24 (1), p.206-206, Article 206</ispartof><rights>2023. The Author(s).</rights><rights>COPYRIGHT 2023 BioMed Central Ltd.</rights><rights>2023. This work is licensed under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>The Author(s) 2023</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c515t-e89747134f8b98088342f9dd2c6e3b32e856d0765c42c8f1ff1fdd653867a7a73</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10337148/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/2838767989?pq-origsite=primo$$EHTML$$P50$$Gproquest$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,25753,27924,27925,37012,37013,44590,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/37438733$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Than, Win Hlaing</creatorcontrib><creatorcontrib>Chan, Gordon Chun-Kau</creatorcontrib><creatorcontrib>Kwan, Bonnie Ching-Ha</creatorcontrib><creatorcontrib>Lai, Ka-Bik</creatorcontrib><creatorcontrib>Chan, Ronald Cheong-Kin</creatorcontrib><creatorcontrib>Teoh, Jeromy Yuen Chun</creatorcontrib><creatorcontrib>Ng, Jack Kit-Chung</creatorcontrib><creatorcontrib>Fung, Winston Wing-Shing</creatorcontrib><creatorcontrib>Chow, Kai-Ming</creatorcontrib><creatorcontrib>Cheng, Phyllis Mei-Shan</creatorcontrib><creatorcontrib>Li, Philip Kam-Tao</creatorcontrib><creatorcontrib>Szeto, Cheuk-Chun</creatorcontrib><title>Plasma vaspin levels and clinical outcome in incident peritoneal dialysis patients</title><title>BMC nephrology</title><addtitle>BMC Nephrol</addtitle><description>Vaspin is an adipokine that regulates glucose and lipid metabolism. Plasma vaspin level is increased in chronic kidney disease but decreased in hemodialysis patients. However, plasma vaspin level in peritoneal dialysis (PD) patients, as well as its prognostic role, has not been studied. We recruited 146 incident PD patients. Their baseline plasma vaspin levels, body anthropometry, the profile of insulin resistance, bioimpedance spectroscopy parameters, dialysis adequacy, and nutritional indices were measured. They were followed for up to 5 years for survival analysis. The average age was 58.4 ± 11.8 years; 96 patients (65.8%) were men, and 90 (61.6%) had diabetes. The median vaspin level was 0.18 ng/dL (interquartile range [IQR] 0.11 to 0.30 ng/dL). Plasma vaspin level did not have a significant correlation with adipose tissue mass or baseline insulin level. However, plasma vaspin level had a modest correlation with the change in insulin resistance, as represented by the HOMA-IR index, in non-diabetic patients (r = -0.358, p = 0.048). Although the plasma vaspin level quartile did not have a significant association with patient survival in the entire cohort, it had a significant interaction with diabetic status (p &lt; 0.001). In nondiabetic patients, plasma vaspin level quartile was an independent predictor of patient survival after adjusting for confounding clinical factors (adjusted hazard ratio 2.038, 95% confidence interval 1.191-3.487, p = 0.009), while the result for diabetic patients was not significant. Plasma vaspin level quartile had a significant association with patient survival in non-diabetic PD patients. 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Chan, Gordon Chun-Kau ; Kwan, Bonnie Ching-Ha ; Lai, Ka-Bik ; Chan, Ronald Cheong-Kin ; Teoh, Jeromy Yuen Chun ; Ng, Jack Kit-Chung ; Fung, Winston Wing-Shing ; Chow, Kai-Ming ; Cheng, Phyllis Mei-Shan ; Li, Philip Kam-Tao ; Szeto, Cheuk-Chun</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c515t-e89747134f8b98088342f9dd2c6e3b32e856d0765c42c8f1ff1fdd653867a7a73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Adipokines</topic><topic>Adipose tissue</topic><topic>Aged</topic><topic>Anthropometry</topic><topic>Atherosclerosis</topic><topic>Body fat</topic><topic>Body mass index</topic><topic>Cardiovascular diseases</topic><topic>Care and treatment</topic><topic>Chronic kidney failure</topic><topic>Clinical outcomes</topic><topic>Continuous ambulatory peritoneal dialysis</topic><topic>Creatinine</topic><topic>Diabetes</topic><topic>Diabetes mellitus</topic><topic>Dialysate</topic><topic>Female</topic><topic>Glucose</topic><topic>Glucose metabolism</topic><topic>Health aspects</topic><topic>Hemodialysis</topic><topic>Humans</topic><topic>Inflammation</topic><topic>Insulin Resistance</topic><topic>Kidney diseases</topic><topic>Kidney transplants</topic><topic>Lipid metabolism</topic><topic>Male</topic><topic>Measurement</topic><topic>Metabolic syndrome</topic><topic>Middle Aged</topic><topic>Mortality</topic><topic>Nephrology</topic><topic>Nutritional status</topic><topic>Obesity</topic><topic>Overweight</topic><topic>Patient outcomes</topic><topic>Patients</topic><topic>Peritoneal Dialysis</topic><topic>Peritoneum</topic><topic>Plasma</topic><topic>Prevention</topic><topic>Renal Dialysis</topic><topic>Renal failure</topic><topic>Risk factors</topic><topic>Serine</topic><topic>Serpins - blood</topic><topic>Spectroscopy</topic><topic>Spectrum analysis</topic><topic>Statistical analysis</topic><topic>Survival</topic><topic>Survival analysis</topic><topic>Variance analysis</topic><topic>Velocity</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Than, Win Hlaing</creatorcontrib><creatorcontrib>Chan, Gordon Chun-Kau</creatorcontrib><creatorcontrib>Kwan, Bonnie Ching-Ha</creatorcontrib><creatorcontrib>Lai, Ka-Bik</creatorcontrib><creatorcontrib>Chan, Ronald Cheong-Kin</creatorcontrib><creatorcontrib>Teoh, Jeromy Yuen Chun</creatorcontrib><creatorcontrib>Ng, Jack Kit-Chung</creatorcontrib><creatorcontrib>Fung, Winston Wing-Shing</creatorcontrib><creatorcontrib>Chow, Kai-Ming</creatorcontrib><creatorcontrib>Cheng, Phyllis Mei-Shan</creatorcontrib><creatorcontrib>Li, Philip Kam-Tao</creatorcontrib><creatorcontrib>Szeto, Cheuk-Chun</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Calcium &amp; 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Plasma vaspin level is increased in chronic kidney disease but decreased in hemodialysis patients. However, plasma vaspin level in peritoneal dialysis (PD) patients, as well as its prognostic role, has not been studied. We recruited 146 incident PD patients. Their baseline plasma vaspin levels, body anthropometry, the profile of insulin resistance, bioimpedance spectroscopy parameters, dialysis adequacy, and nutritional indices were measured. They were followed for up to 5 years for survival analysis. The average age was 58.4 ± 11.8 years; 96 patients (65.8%) were men, and 90 (61.6%) had diabetes. The median vaspin level was 0.18 ng/dL (interquartile range [IQR] 0.11 to 0.30 ng/dL). Plasma vaspin level did not have a significant correlation with adipose tissue mass or baseline insulin level. However, plasma vaspin level had a modest correlation with the change in insulin resistance, as represented by the HOMA-IR index, in non-diabetic patients (r = -0.358, p = 0.048). Although the plasma vaspin level quartile did not have a significant association with patient survival in the entire cohort, it had a significant interaction with diabetic status (p &lt; 0.001). In nondiabetic patients, plasma vaspin level quartile was an independent predictor of patient survival after adjusting for confounding clinical factors (adjusted hazard ratio 2.038, 95% confidence interval 1.191-3.487, p = 0.009), while the result for diabetic patients was not significant. Plasma vaspin level quartile had a significant association with patient survival in non-diabetic PD patients. Baseline plasma vaspin level also had a modest inverse correlation with the subsequent change in the severity of insulin resistance, but the exact biological role of vaspin deserves further studies.</abstract><cop>England</cop><pub>BioMed Central Ltd</pub><pmid>37438733</pmid><doi>10.1186/s12882-023-03259-2</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record>
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source Open Access: PubMed Central; Publicly Available Content Database
subjects Adipokines
Adipose tissue
Aged
Anthropometry
Atherosclerosis
Body fat
Body mass index
Cardiovascular diseases
Care and treatment
Chronic kidney failure
Clinical outcomes
Continuous ambulatory peritoneal dialysis
Creatinine
Diabetes
Diabetes mellitus
Dialysate
Female
Glucose
Glucose metabolism
Health aspects
Hemodialysis
Humans
Inflammation
Insulin Resistance
Kidney diseases
Kidney transplants
Lipid metabolism
Male
Measurement
Metabolic syndrome
Middle Aged
Mortality
Nephrology
Nutritional status
Obesity
Overweight
Patient outcomes
Patients
Peritoneal Dialysis
Peritoneum
Plasma
Prevention
Renal Dialysis
Renal failure
Risk factors
Serine
Serpins - blood
Spectroscopy
Spectrum analysis
Statistical analysis
Survival
Survival analysis
Variance analysis
Velocity
title Plasma vaspin levels and clinical outcome in incident peritoneal dialysis patients
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