Primary Mediastinal Large B-Cell Lymphoma As an Incidental Finding: Report of a Case

A 21-year-old female was examined for an incidentally detected left parahilar mass on chest radiograph which was taken at the time of job application (Figure 1a). Thoracic computed tomography revealed a mass of 10x9x5 cm with irregular lobulated borders in the anterior mediastinum invading the peric...

Full description

Saved in:
Bibliographic Details
Published in:Turkish journal of haematology 2018-05, Vol.35 (2), p.141-142
Main Authors: Yönal-Hindilerden, İpek, Hindilerden, Fehmi, Arslan, Serkan, Doğan, İbrahim Öner, Nalçacı, Meliha
Format: Article
Language:English
Subjects:
b-cell lymphoma
Hematology
Letters to the Editor
Lymphoma
mediastinal neoplasm
pmbcl
Tıp
Tomography
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:A 21-year-old female was examined for an incidentally detected left parahilar mass on chest radiograph which was taken at the time of job application (Figure 1a). Thoracic computed tomography revealed a mass of 10x9x5 cm with irregular lobulated borders in the anterior mediastinum invading the pericardium (Figure 1b). Histopathological examination of the anterior mediastinotomy material revealed large neoplastic B cells staining positive for CD20 and MUM-1, negative for CD10, and with a high Ki-67 proliferation index (80%-90%) (Figure 2). On positron-emission tomography scan, only the mediastinal mass showed increased fludeoxyglucose uptake (SUVmax: 18) (Figure 1c). Final diagnosis was stage 1A primary mediastinal large B-cell lymphoma (PMBCL). After 6 cycles of R-CHOP, PET scan showed partial anatomical and metabolic response. R-CHOP was completed to 8 cycles followed by mediastinal radiation. She has now been disease-free for 2 years.
ISSN:1300-7777
1308-5263
DOI:10.4274/tjh.2016.0057