Anatomical Brain Changes and Cognitive Abilities in Patients with Obstructive Sleep Apnea Syndrome and Nonalcoholic Fatty Liver Disease

Obstructive sleep apnea (OSA) is characterized by repetitive complete or partial collapse of the upper airway and reduction of airflow during sleep. It is associated with significantly increased daytime muscle sympathetic nerve activity thought to result from the repetitive intermittent periods of h...

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Bibliographic Details
Published in:Canadian journal of gastroenterology & hepatology 2021, Vol.2021, p.1-11
Main Authors: Filipovic, Branka, Đuric, Vesna, Filipovic, Natasa, Kiurski, Stanimir, Al Kiswani, Jamal, Markovic, Branka, Laketic, Darko, Marjanovic-Haljilji, Marija, Kapor, Slobodan, Filipovic, Branislav R.
Format: Article
Language:English
Subjects:
Atherosclerosis
Caffeine
Cholesterol
Cognitive ability
Dementia
Drugs
Hepatitis
High density lipoprotein
Hypoxemia
Hypoxia
Liver diseases
Magnetic resonance imaging
Memory
Oxygen saturation
Sleep apnea
Triglycerides
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Summary:Obstructive sleep apnea (OSA) is characterized by repetitive complete or partial collapse of the upper airway and reduction of airflow during sleep. It is associated with significantly increased daytime muscle sympathetic nerve activity thought to result from the repetitive intermittent periods of hypoxemia during sleep and brain alterations that are likely to result. Different brain regions are affected by subsequent hypoxia/anoxia. Neurodegenerative processes result in measurable atrophy of cortical gray matter in the temporal lobes and posterior cingulate cortex, as well as in subcortical structures such as the hippocampus, amygdala, and thalamus. This study involved a group of firstly diagnosed, therapy-naive, nonalcoholic fatty liver disease (NAFLD) patients, out of which 144 (96 males and 48 females), aged 34–57 (mean 47.88 ± 6.07), satisfied the recruiting criteria for the study and control groups. All the patients underwent MRI scanning, polysomnography testing, and cognitive evaluation. Cognitively, worse results were obtained in the group with OSA (p
ISSN:2291-2789
2291-2797
DOI:10.1155/2021/8873652