Autoinflammation in psoriatic arthritis: time to better define the multifaceted enemy

Psoriatic arthritis (PsA) is a very heterogeneous disease involving the skin, joints, eyes, gastrointestinal and cardiometabolic systems.1 In the perspective of ‘psoriatic syndrome’ or ‘psoriatic disease’, PsA is a distinct, important and complex entity.1 PsA is a mysterious disease and still bears...

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Bibliographic Details
Published in:Rheumatic & musculoskeletal diseases open 2022-11, Vol.8 (2), p.e002685
Main Author: Bilgin, Emre
Format: Article
Language:English
Subjects:
Arthritis, Psoriatic
Immune System Diseases
Inflammation
Pathogenesis
Psoriatic arthritis
Spondyloarthritis
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Summary:Psoriatic arthritis (PsA) is a very heterogeneous disease involving the skin, joints, eyes, gastrointestinal and cardiometabolic systems.1 In the perspective of ‘psoriatic syndrome’ or ‘psoriatic disease’, PsA is a distinct, important and complex entity.1 PsA is a mysterious disease and still bears many aspects to explore. For instance, although we know many things about the relationship between psoriasis (PsO) and PsA—even though we have a long road to go—it took about 18 centuries for the literature to report this relationship after the papers published about PsO.2 On the other hand, the mystery is being explored day by day, especially about pathogenesis. Till now, current literature has been focused on the autoimmune aspects of PsA pathogenesis, for example, human leucocyte antigens and clonal expansions of CD8+ T cells.3 Although a few genome-wide association studies and small studies found PsA and PsO susceptibility genes related to innate immunity,4 no study has focused on the individual patient-level role of autoinflammatory disorder genes in PsA patients.
ISSN:2056-5933
2056-5933
DOI:10.1136/rmdopen-2022-002685