Directional and Strain-Specific Interaction Between Lactobacillus plantarum and Staphylococcus aureus

The interaction between and strains FRI-1169 and MN8, two original isolated strains from menstrual toxic shock syndrome (mTSS) cases, is a key focus for developing non-antibiotic strategies to control -related infections. While the antagonistic effects of species on through mechanisms like organic a...

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Bibliographic Details
Published in:Microorganisms (Basel) 2024-11, Vol.12 (12), p.2432
Main Authors: Kondakala, Sandeep, Yoon, Sunghyun, Daddy Gaoh, Soumana, Kweon, Ohgew, Kim, Seong-Jae, Hart, Mark E
Format: Article
Language:English
Subjects:
Acids
Amino acids
Antagonism
Antibiotics
Bacteria
Bacteriocins
Culture media
Drug resistance
Ethylenediaminetetraacetic acid
Glycerol
Health aspects
Laboratories
Lactobacilli
Lactobacillus plantarum
Menstruation
Metabolism
Molecular dynamics
Molecular modelling
non-antibiotic biocontrol agent
Organic acids
Proteins
Proteomics
Septic shock
Staphylococcus aureus
Staphylococcus aureus infection
Staphylococcus aureus infections
Strains (organisms)
Toxic shock syndrome
Toxins
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Summary:The interaction between and strains FRI-1169 and MN8, two original isolated strains from menstrual toxic shock syndrome (mTSS) cases, is a key focus for developing non-antibiotic strategies to control -related infections. While the antagonistic effects of species on through mechanisms like organic acid and bacteriocin production are known, the molecular dynamics of these interactions remain underexplored. This study employs a proteomic approach to analyze the interactions between WCFS1 and strains, FRI-1169 and MN8, during co-culture. We profiled differentially expressed proteins (DEPs) found in the spent media and cytosols of both bacteria, revealing distinct directional and strain-specific responses. The findings demonstrate that exerts a more pronounced effect on , with more DEPs and upregulated proteins, while showed fewer DEPs and more downregulated proteins. These strain-specific interactions highlight the complex metabolic and regulatory adjustments between these bacterial species. This research provides valuable insights into the molecular mechanisms of antagonism and underscores the potential of proteomic analysis as a powerful tool for studying bacterial dynamics in co-culture systems.
ISSN:2076-2607
2076-2607
DOI:10.3390/microorganisms12122432