Circulating CTRP1 Levels in Type 2 Diabetes and Their Association with FGF21

The goal of this study was to investigate whether circulating C1q/TNF-α-related protein 1 (CTRP1) levels are associated with diabetes. In addition, relationships between CTRP1 and other diabetes-related cytokines were elucidated, including adiponectin and fibroblast growth factor 21 (FGF21). A total...

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Bibliographic Details
Published in:International Journal of Endocrinology 2016-01, Vol.2016 (2016), p.708-714-079
Main Authors: Lee, Won-Young, Yang, Young, Rhee, Eun-Jung, Boldbaatar, Ariundavaa, Yong, Hyo Jeong, Park, Jeong Su, Jeong, Ae Lee, Lee, Sunyi, Kim, Jong Dai, Han, Sora, Ka, Hye In
Format: Article
Language:English
Subjects:
Age
Blood pressure
Body mass index
Cholesterol
Development and progression
Diabetes
Endocrinology
Fatty acids
Fibroblast growth factors
Genetic aspects
Glucose
Homeostasis
Hormones
Hospitals
Insulin resistance
Laboratories
Medical screening
Metabolism
Patients
Physiological aspects
Proteins
Studies
Triglycerides
Tumor necrosis factor
Tumor necrosis factor-TNF
Type 2 diabetes
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Summary:The goal of this study was to investigate whether circulating C1q/TNF-α-related protein 1 (CTRP1) levels are associated with diabetes. In addition, relationships between CTRP1 and other diabetes-related cytokines were elucidated, including adiponectin and fibroblast growth factor 21 (FGF21). A total of 178 subjects (78 men and 100 women) aged 29–70 years (mean age, 46.1 years) were randomly selected. The sera from a normal glucose tolerance group ( n = 68 ) and a prediabetes/type 2 diabetes group ( n = 1 10 ) were collected; then, circulating levels of CTRP1, adiponectin, and FGF21 were determined via enzyme-linked immunosorbent assay in all sera. Subjects with either prediabetes or diabetes exhibited higher circulating CTRP1 levels than healthy subjects. Sera analysis revealed that CTRP1 was positively correlated with age, body mass index, fasting blood glucose, and circulating FGF21 levels. However, CTRP1 was negatively correlated with total cholesterol and total circulating adiponectin levels in univariate analysis. In addition, multivariate analysis found that CTRP1 was independently associated with age, fasting blood glucose, and circulating FGF21 levels. CTRP1 was correlated with homeostasis model assessment-β (HOMA-β), but no correlation was observed with HOMA-insulin resistance. In conclusion, circulating CTRP1 levels are increased in subjects with type 2 diabetes and are positively associated with circulating FGF21 levels.
ISSN:1687-8337
1687-8345
DOI:10.1155/2016/5479627