Adolescent rats are resistant to forming ethanol seeking habits

• Published in: Developmental cognitive neuroscience 2015-12, Vol.16 (C), p.183-190
• Main Authors: Serlin, Hannah, Torregrossa, Mary M.
• Format: Article
• Language: English
• Subjects: Adolescent; Aging; Alcohol; Alcohol Drinking - psychology; Alcoholism - etiology; Alcoholism - psychology; Animals; Conditioning, Operant - drug effects; Contingency degradation; Drug-Seeking Behavior; Extinction, Psychological - drug effects; Goal-directed; Habit; Male; Original Research; Rats; Rats, Sprague-Dawley; Self Administration
• ISSN: 1878-9293; 1878-9307
• DOI: 10.1016/j.dcn.2014.12.002

•Adult rats develop ethanol-seeking habits more rapidly than adolescents.•Adolescents appear resistant to the habit promoting effects of ethanol.•Adolescent rats self-administer more ethanol than adults.•Adolescent onset ethanol self-administration results in greater self-administration in adulthood. Early age of onset alcohol drinking is significantly more likely to lead to alcohol use disorders (AUDs) than alcohol drinking that begins after the age of 18. Unfortunately, the majority of people in the United States begin drinking in adolescence. Therefore, it is important to understand how early alcohol drinking leads to increased risk for AUDs so that better treatments and prevention strategies can be developed. Adolescents perceive greater rewarding properties of alcohol, and adolescents may be more likely to form alcohol-seeking habits that promote continued use throughout the lifetime. Therefore, we compared the development of alcohol seeking habits in adolescent and adult male, Sprague-Dawley rats. Rats were trained to lever press to receive 10% ethanol+0.1% saccharin on a schedule that promotes habit formation. Rats were tested using a contingency degradation procedure at different points in training. Adult rats formed ethanol-seeking habits with only moderate training, while adolescents remained goal-directed even with extended training. Nevertheless, adolescents consumed more ethanol than adults throughout the experiment and continued to consume more ethanol than adults when they reached adulthood. Therefore, early onset alcohol use may promote AUD formation through establishment of high levels of drinking that becomes habitual in adulthood.