The Effects of Various Metallic Surfaces on Cellular and Bacterial Adhesion

The effects of Ti, Nb, Ta, Zr, and Ag on cellular and bacterial adhesion were investigated in this study. Moreover, the relationships between surface compositions, metal ion release behaviors, and biological responses were examined. As a result, MC3T3-E1 cells and S. aureus were able to better attac...

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Bibliographic Details
Published in:Metals (Basel ) 2019-11, Vol.9 (11), p.1145
Main Authors: Shimabukuro, Masaya, Ito, Haruka, Tsutsumi, Yusuke, Nozaki, Kosuke, Chen, Peng, Yamada, Risa, Ashida, Maki, Nagai, Akiko, Hanawa, Takao
Format: Article
Language:English
Subjects:
antibacterial activity
Bacteria
biocompatibility
biofilm
Biofilms
Cell adhesion
Cell culture
Corrosion resistance
cytotoxicity
Ethanol
Medical research
Niobium
silver
Tantalum
Titanium
Zirconium
β-stabilizer elements
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Summary:The effects of Ti, Nb, Ta, Zr, and Ag on cellular and bacterial adhesion were investigated in this study. Moreover, the relationships between surface compositions, metal ion release behaviors, and biological responses were examined. As a result, MC3T3-E1 cells and S. aureus were able to better attach to Ti and Zr rather than the Nb and Ta specimens. For the Ag specimen, the amount of Ag ions released into Hanks’ solution was the largest among all the specimens. Cellular and bacterial adhesion onto the Ag specimen was inhibited compared with the other specimens, because of Ag ion release. Alternatively, Nb and Ta specimens exhibited specific biological responses. Cellular adhesion on Nb and Ta specimens was similar to that on Ti, while bacterial adhesion on Nb and Ta specimens was inhibited compared with that on Ti. This study proved that Nb and Ta inhibited bacterial adhesion and exhibited no harmful effects on cellular adhesion. In addition, these results indicate that the passive layer on Nb and Ta plays a key role in the inhibition of bacterial adhesion.
ISSN:2075-4701
2075-4701
DOI:10.3390/met9111145