Hydrogen Sulfide Attenuates β2-Microglobulin-Induced Cognitive Dysfunction: Involving Recovery of Hippocampal Autophagic Flux

Accumulation of β -microglobulin (B2M), a systemic pro-aging factor, regulates negatively cognitive function. Hydrogen sulfide (H S), a novel gas signaling molecule, exerts protection against cognitive dysfunction. Therefore, the present work was designed to explore whether H S attenuates cognitive...

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Bibliographic Details
Published in:Frontiers in behavioral neuroscience 2019-10, Vol.13, p.244
Main Authors: Chen, Si-Min, Yi, Yi-Li, Zeng, Dan, Tang, Yi-Yun, Kang, Xuan, Zhang, Ping, Zou, Wei, Tang, Xiao-Qing
Format: Article
Language:English
Subjects:
Aging
Animal cognition
Apoptosis
autophagic flux
Autophagy
Cognitive ability
cognitive dysfunction
Endoplasmic reticulum
Hippocampus
Homocysteine
Hydrogen
Hydrogen sulfide
Laboratory animals
Memory
Morphology
Neuroscience
p62 Protein
Pattern recognition
Rodents
Transmission electron microscopy
β2 Microglobulin
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Summary:Accumulation of β -microglobulin (B2M), a systemic pro-aging factor, regulates negatively cognitive function. Hydrogen sulfide (H S), a novel gas signaling molecule, exerts protection against cognitive dysfunction. Therefore, the present work was designed to explore whether H S attenuates cognitive dysfunction induced by B2M and the underlying mechanism. The cognitive function of rats was assessed by Y-maze, Novel object recognition (NOR), and Morris water maze (MWM) tests. The levels of autophagosome and autolysosome in hippocampus were observed by transmission electron microscopy. The expression of p62 protein in hippocampus was detected by western blot analysis. NaHS (a donor of H S) significantly alleviated cognitive impairments in the B2M-exposed rats tested by Y-maze test, NOR test and MWM test. Furthermore, NaHS recovered autophagic flux in the hippocampus of B2M-exposed rats, as evidenced by decreases in the ratio of autophagosome to autolysosome and the expression of p62 protein in the hippocampus. In summary, these data indicated that H S attenuates B2M-induced cognitive dysfunction, involving in recovery of the blocked autophagic flux in the hippocampus, and suggested that H S may be a novel approach to prevent B2M-induced cognitive dysfunction.
ISSN:1662-5153
1662-5153
DOI:10.3389/fnbeh.2019.00244