Virulence Genes and Antimicrobial Resistance Profiles of Pasteurella multocida Strains Isolated from Rabbits in Brazil

Pasteurella multocida is responsible for a wide range of diseases in domestic animals. In rabbits, the agent is related to nasal discharge, pneumonia, otitis media, pyometra, orchitis, abscess, and septicemia. One hundred and forty rabbits with respiratory diseases from four rabbitries in São Paulo...

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Bibliographic Details
Published in:TheScientificWorld 2012-01, Vol.2012 (2012), p.1-6
Main Authors: Porfida Ferreira, Thais Sebastiana, Felizardo, Maria Roberta, Gobbi, Debora Dirani Sena de, Gomes, Cleise Ribeiro, Nogueira Filsner, Pedro Henrique de Lima, Moreno, Marina, Paixão, Renata, Pereira, Jucélia de Jesus, Moreno, Andrea Micke
Format: Article
Language:English
Subjects:
Amoxicillin
Animal diseases
Animals
Antimicrobial agents
Antimicrobial resistance
Biochemical tests
Cotrimoxazole
Deoxyribonucleic acid
Disease
DNA
Domestic animals
Drug resistance
Drug Resistance, Microbial - genetics
Epidemiology
Erythromycin
Gene frequency
Genes
Infections
Microbial Sensitivity Tests
Orchitis
Otitis media
Pasteurella multocida
Pasteurella multocida - drug effects
Pasteurella multocida - genetics
Penicillin
Polymerase Chain Reaction
Rabbits
Respiratory diseases
Septicemia
Sulfonamides
Veterinary medicine
Virulence
Virulence - genetics
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Summary:Pasteurella multocida is responsible for a wide range of diseases in domestic animals. In rabbits, the agent is related to nasal discharge, pneumonia, otitis media, pyometra, orchitis, abscess, and septicemia. One hundred and forty rabbits with respiratory diseases from four rabbitries in São Paulo State, Brazil were evaluated for the detection of P. multocida in their nasal cavities. A total of twenty-nine animals were positive to P. multocida isolation, and 46 strains were selected and characterized by means of biochemical tests and PCR. P. multocida strains were tested for capsular type, virulence genes, and resistance profile. A total of 45.6% (21/46) of isolates belonged to capsular type A, and 54.34% (25/46) of the isolates were untypeable. None of the strains harboured toxA or pfhA genes. The frequency of the other twenty genes tested was variable, and the data generated was used to build a dendrogram, showing the relatedness of strains, which were clustered according to origin. Resistance revealed to be more common against sulfonamides and cotrimoxazole, followed by erythromycin, penicillin, and amoxicillin.
ISSN:2356-6140
1537-744X
1537-744X
DOI:10.1100/2012/685028