The correlation between serum vitamin D levels and cutaneous involvement in metabolic syndrom

• Published in: Revista medicală Română 2017-12, Vol.64 (4), p.300-304
• Main Authors: Ioana Veronica Grăjdeanu, Gabriel Cristian Bejan, Mihaela Adela Iancu, Ekua Asafoaba Appiah, Răzvan Peagu, Dumitru Matei
• Format: Article
• Language: English
• Subjects: psoriasis; tmetabolic syndrome; vitamin d
• ISSN: 1220-5478; 2069-606X
• DOI: 10.37897/RMJ.2017.4.8

Aims. The rising global trend of metabolic syndrome cases has increased the problems associated with decreasing serum vitamin D levels and the likelihood of cutaneous involvement. This research was aimed at determining the prevalence of metabolic syndrome, the distribution of its components and correlation the between serum vitamin D levels and possible skin involvement in the patients. Materials and methods. The study of Romanian citizens was conducted between 2010 and 2017, involved mainly urban dwellers with a median age of 18. The parameters measured included physical examination and fasting blood tests. The criteria of the International Diabetes Federation (IDF) was used for the metabolic syndrome diagnosis. The serum 25 (OH) D levels were based on the laboratory reference values and the severity of psoriasis was calculated according to the BSA score. Results. The total number of participants in the study was 634, of which 36% were diagnosed with metabolic syndrome, with a 59% prevalence of females. The distribution of the components of the metabolic syndrome was: 100% increased waist circumference (mandatory component for diagnosis), hyperglycaemia 53.7%, low HDL cholesterol 44.9%, triglyceride increase 26.4%, high blood pressure 21.6%. Low serum vitamin D levels were found at 54.6%. Psoriasis showed 46.2% of all those with metabolic syndrome. Conclusion. After thorough analysis of the data, it can be concluded that there is a relationship between the presence of metabolic syndrome and serum vitamin D, the latter being mostly low in the studied group. The more the components of metabolic syndrome are present, the lower the vitamin D serum level. The presence of psoriasis can aggravate metabolic syndrome components and vitamin D serum decline. Further studies can determine whether serum vitamin D normalization can bring improvements in metabolic syndrome components.