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Concomitant preoperative airflow obstruction confers worse prognosis after trans-thoracic surgery for esophageal cancer
Airflow obstruction is a critical element of chronic airway diseases. This study aimed to evaluate the impact of preoperative airflow obstruction on the prognosis of patients following surgery for esophageal carcinoma. A total of 821 esophageal cancer patients were included and classified into two g...
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| Published in: | Frontiers in surgery 2023-01, Vol.9, p.966340-966340 |
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| creator | Lang, Ke Wang, Xiaocen Wei, Tingting Gu, Zhaolin Song, Yansha Yang, Dong Wang, Hao |
| description | Airflow obstruction is a critical element of chronic airway diseases. This study aimed to evaluate the impact of preoperative airflow obstruction on the prognosis of patients following surgery for esophageal carcinoma.
A total of 821 esophageal cancer patients were included and classified into two groups based on whether or not they had preoperative airflow obstruction. Airflow obstruction was defined as a forced expiration volume in the first second (FEV
)/forced vital capacity (FVC) ratio below the lower limit of normal (LLN). A retrospective analysis of the impact of airflow obstruction on the survival of patients with esophageal carcinoma undergoing esophagectomy was performed.
Patients with airflow obstruction (102/821, 12.4%) had lower three-year overall (42/102, 58.8%) and progression-free survival rate (47/102, 53.9%) than those without airflow obstruction ( |
| doi_str_mv | 10.3389/fsurg.2022.966340 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_doaj_</sourceid><recordid>TN_cdi_doaj_primary_oai_doaj_org_article_cd3ba21d0cb04e06a3dcfe11aa9f990e</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><doaj_id>oai_doaj_org_article_cd3ba21d0cb04e06a3dcfe11aa9f990e</doaj_id><sourcerecordid>2771939766</sourcerecordid><originalsourceid>FETCH-LOGICAL-c465t-f61a797316958eed85452e7862aa562f2fd41d26c09177b0f7f8e9dd4ebf00a93</originalsourceid><addsrcrecordid>eNpVkU1r3DAQhk1pacI2P6CXomMv3urDlqxLoSz9CAR6aaE3MZZGXgWv5Upylvz7erNpSE4apJlH7_BU1XtGt0J0-pPPSxq2nHK-1VKKhr6qLjnXsu5U--f1s_qiusr5llLKRMMkb95WF0IqLnXLLqvjLk42HkKBqZA5YZwxQQl3SCAkP8YjiX0uabElxInYOHlMmRxjyri2x2GKOWQCvmAiJcGU67KPCWyw5JQP0z3xMRHMcd7DgDASC5PF9K5642HMePV4bqrf377-2v2ob35-v959ualtI9tSe8lAaSXYmrZDdF3btBxVJzlAK7nn3jXMcWmpZkr11CvfoXauwd5TClpsqusz10W4NXMKB0j3JkIwDxcxDQZSCXZEY53ogTNHbU8bpBKEsx4ZA9Bea4or6_OZNS_9AZ3Fad14fAF9-TKFvRnindFd13KqVsDHR0CKfxfMxRxCtjiOMGFcsuFKMS20WnVuKnZutSnmnNA_fcOoOfk3D_7Nyb85-19nPjzP9zTx37b4BzDJsms</addsrcrecordid><sourcetype>Open Website</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2771939766</pqid></control><display><type>article</type><title>Concomitant preoperative airflow obstruction confers worse prognosis after trans-thoracic surgery for esophageal cancer</title><source>PubMed Central</source><creator>Lang, Ke ; Wang, Xiaocen ; Wei, Tingting ; Gu, Zhaolin ; Song, Yansha ; Yang, Dong ; Wang, Hao</creator><creatorcontrib>Lang, Ke ; Wang, Xiaocen ; Wei, Tingting ; Gu, Zhaolin ; Song, Yansha ; Yang, Dong ; Wang, Hao</creatorcontrib><description>Airflow obstruction is a critical element of chronic airway diseases. This study aimed to evaluate the impact of preoperative airflow obstruction on the prognosis of patients following surgery for esophageal carcinoma.
A total of 821 esophageal cancer patients were included and classified into two groups based on whether or not they had preoperative airflow obstruction. Airflow obstruction was defined as a forced expiration volume in the first second (FEV
)/forced vital capacity (FVC) ratio below the lower limit of normal (LLN). A retrospective analysis of the impact of airflow obstruction on the survival of patients with esophageal carcinoma undergoing esophagectomy was performed.
Patients with airflow obstruction (102/821, 12.4%) had lower three-year overall (42/102, 58.8%) and progression-free survival rate (47/102, 53.9%) than those without airflow obstruction (
< 0.001). Multivariate analyses showed that airflow obstruction was an independent risk factor for overall survival (Hazard Ratio = 1.66; 95% CI: 1.17-2.35,
= 0.004) and disease progression (Hazard Ratio = 1.51; 95% CI: 1.1-2.08;
0.01). A subgroup analysis revealed that the above results were more significant in male patients, BMI < 23 kg/m
patients or late-stage cancer (stage III-IVA) (
= 0.001) patients and those undergoing open esophagectomy (
< 0.001).
Preoperative airflow obstruction defined by FEV
/FVC ratio below LLN was an independent risk factor for mortality in esophageal cancer patients after trans-thoracic esophagectomy. Comprehensive management of airflow obstruction and more personalized surgical decision-making are necessary to improve survival outcomes in esophageal cancer patients.</description><identifier>ISSN: 2296-875X</identifier><identifier>EISSN: 2296-875X</identifier><identifier>DOI: 10.3389/fsurg.2022.966340</identifier><identifier>PMID: 36726951</identifier><language>eng</language><publisher>Switzerland: Frontiers Media S.A</publisher><subject>airflow obstruction ; decision-making ; esophageal cancer ; lung function ; Surgery ; survival</subject><ispartof>Frontiers in surgery, 2023-01, Vol.9, p.966340-966340</ispartof><rights>2023 Lang, Wang, Wei, Gu, Song, Yang and Wang.</rights><rights>2023 Lang, Wang, Wei, Gu, Song, Yang and Wang. 2023 Lang, Wang, Wei, Gu, Song, Yang and Wang</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c465t-f61a797316958eed85452e7862aa562f2fd41d26c09177b0f7f8e9dd4ebf00a93</citedby><cites>FETCH-LOGICAL-c465t-f61a797316958eed85452e7862aa562f2fd41d26c09177b0f7f8e9dd4ebf00a93</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9885207/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9885207/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36726951$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lang, Ke</creatorcontrib><creatorcontrib>Wang, Xiaocen</creatorcontrib><creatorcontrib>Wei, Tingting</creatorcontrib><creatorcontrib>Gu, Zhaolin</creatorcontrib><creatorcontrib>Song, Yansha</creatorcontrib><creatorcontrib>Yang, Dong</creatorcontrib><creatorcontrib>Wang, Hao</creatorcontrib><title>Concomitant preoperative airflow obstruction confers worse prognosis after trans-thoracic surgery for esophageal cancer</title><title>Frontiers in surgery</title><addtitle>Front Surg</addtitle><description>Airflow obstruction is a critical element of chronic airway diseases. This study aimed to evaluate the impact of preoperative airflow obstruction on the prognosis of patients following surgery for esophageal carcinoma.
A total of 821 esophageal cancer patients were included and classified into two groups based on whether or not they had preoperative airflow obstruction. Airflow obstruction was defined as a forced expiration volume in the first second (FEV
)/forced vital capacity (FVC) ratio below the lower limit of normal (LLN). A retrospective analysis of the impact of airflow obstruction on the survival of patients with esophageal carcinoma undergoing esophagectomy was performed.
Patients with airflow obstruction (102/821, 12.4%) had lower three-year overall (42/102, 58.8%) and progression-free survival rate (47/102, 53.9%) than those without airflow obstruction (
< 0.001). Multivariate analyses showed that airflow obstruction was an independent risk factor for overall survival (Hazard Ratio = 1.66; 95% CI: 1.17-2.35,
= 0.004) and disease progression (Hazard Ratio = 1.51; 95% CI: 1.1-2.08;
0.01). A subgroup analysis revealed that the above results were more significant in male patients, BMI < 23 kg/m
patients or late-stage cancer (stage III-IVA) (
= 0.001) patients and those undergoing open esophagectomy (
< 0.001).
Preoperative airflow obstruction defined by FEV
/FVC ratio below LLN was an independent risk factor for mortality in esophageal cancer patients after trans-thoracic esophagectomy. Comprehensive management of airflow obstruction and more personalized surgical decision-making are necessary to improve survival outcomes in esophageal cancer patients.</description><subject>airflow obstruction</subject><subject>decision-making</subject><subject>esophageal cancer</subject><subject>lung function</subject><subject>Surgery</subject><subject>survival</subject><issn>2296-875X</issn><issn>2296-875X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>DOA</sourceid><recordid>eNpVkU1r3DAQhk1pacI2P6CXomMv3urDlqxLoSz9CAR6aaE3MZZGXgWv5Upylvz7erNpSE4apJlH7_BU1XtGt0J0-pPPSxq2nHK-1VKKhr6qLjnXsu5U--f1s_qiusr5llLKRMMkb95WF0IqLnXLLqvjLk42HkKBqZA5YZwxQQl3SCAkP8YjiX0uabElxInYOHlMmRxjyri2x2GKOWQCvmAiJcGU67KPCWyw5JQP0z3xMRHMcd7DgDASC5PF9K5642HMePV4bqrf377-2v2ob35-v959ualtI9tSe8lAaSXYmrZDdF3btBxVJzlAK7nn3jXMcWmpZkr11CvfoXauwd5TClpsqusz10W4NXMKB0j3JkIwDxcxDQZSCXZEY53ogTNHbU8bpBKEsx4ZA9Bea4or6_OZNS_9AZ3Fad14fAF9-TKFvRnindFd13KqVsDHR0CKfxfMxRxCtjiOMGFcsuFKMS20WnVuKnZutSnmnNA_fcOoOfk3D_7Nyb85-19nPjzP9zTx37b4BzDJsms</recordid><startdate>20230116</startdate><enddate>20230116</enddate><creator>Lang, Ke</creator><creator>Wang, Xiaocen</creator><creator>Wei, Tingting</creator><creator>Gu, Zhaolin</creator><creator>Song, Yansha</creator><creator>Yang, Dong</creator><creator>Wang, Hao</creator><general>Frontiers Media S.A</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20230116</creationdate><title>Concomitant preoperative airflow obstruction confers worse prognosis after trans-thoracic surgery for esophageal cancer</title><author>Lang, Ke ; Wang, Xiaocen ; Wei, Tingting ; Gu, Zhaolin ; Song, Yansha ; Yang, Dong ; Wang, Hao</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c465t-f61a797316958eed85452e7862aa562f2fd41d26c09177b0f7f8e9dd4ebf00a93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>airflow obstruction</topic><topic>decision-making</topic><topic>esophageal cancer</topic><topic>lung function</topic><topic>Surgery</topic><topic>survival</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lang, Ke</creatorcontrib><creatorcontrib>Wang, Xiaocen</creatorcontrib><creatorcontrib>Wei, Tingting</creatorcontrib><creatorcontrib>Gu, Zhaolin</creatorcontrib><creatorcontrib>Song, Yansha</creatorcontrib><creatorcontrib>Yang, Dong</creatorcontrib><creatorcontrib>Wang, Hao</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>Directory of Open Access Journals</collection><jtitle>Frontiers in surgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lang, Ke</au><au>Wang, Xiaocen</au><au>Wei, Tingting</au><au>Gu, Zhaolin</au><au>Song, Yansha</au><au>Yang, Dong</au><au>Wang, Hao</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Concomitant preoperative airflow obstruction confers worse prognosis after trans-thoracic surgery for esophageal cancer</atitle><jtitle>Frontiers in surgery</jtitle><addtitle>Front Surg</addtitle><date>2023-01-16</date><risdate>2023</risdate><volume>9</volume><spage>966340</spage><epage>966340</epage><pages>966340-966340</pages><issn>2296-875X</issn><eissn>2296-875X</eissn><abstract>Airflow obstruction is a critical element of chronic airway diseases. This study aimed to evaluate the impact of preoperative airflow obstruction on the prognosis of patients following surgery for esophageal carcinoma.
A total of 821 esophageal cancer patients were included and classified into two groups based on whether or not they had preoperative airflow obstruction. Airflow obstruction was defined as a forced expiration volume in the first second (FEV
)/forced vital capacity (FVC) ratio below the lower limit of normal (LLN). A retrospective analysis of the impact of airflow obstruction on the survival of patients with esophageal carcinoma undergoing esophagectomy was performed.
Patients with airflow obstruction (102/821, 12.4%) had lower three-year overall (42/102, 58.8%) and progression-free survival rate (47/102, 53.9%) than those without airflow obstruction (
< 0.001). Multivariate analyses showed that airflow obstruction was an independent risk factor for overall survival (Hazard Ratio = 1.66; 95% CI: 1.17-2.35,
= 0.004) and disease progression (Hazard Ratio = 1.51; 95% CI: 1.1-2.08;
0.01). A subgroup analysis revealed that the above results were more significant in male patients, BMI < 23 kg/m
patients or late-stage cancer (stage III-IVA) (
= 0.001) patients and those undergoing open esophagectomy (
< 0.001).
Preoperative airflow obstruction defined by FEV
/FVC ratio below LLN was an independent risk factor for mortality in esophageal cancer patients after trans-thoracic esophagectomy. Comprehensive management of airflow obstruction and more personalized surgical decision-making are necessary to improve survival outcomes in esophageal cancer patients.</abstract><cop>Switzerland</cop><pub>Frontiers Media S.A</pub><pmid>36726951</pmid><doi>10.3389/fsurg.2022.966340</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | airflow obstruction decision-making esophageal cancer lung function Surgery survival |
| title | Concomitant preoperative airflow obstruction confers worse prognosis after trans-thoracic surgery for esophageal cancer |
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