MiRNA-based "fitness score" to assess the individual response to diet, metabolism, and exercise

Regular, especially sustained exercise plays an important role in the prevention and treatment of multiple chronic diseases. Some of the underlying molecular and cellular mechanisms behind the adaptive response to physical activity are still unclear, but recent findings suggest a possible role of ep...

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Bibliographic Details
Published in:Journal of the International Society of Sports Nutrition 2022, Vol.19 (1), p.455-473
Main Authors: Krammer, Ulrike D B, Tschida, Sylvia, Berner, Julia, Lilja, Stephanie, Switzeny, Olivier J, Hippe, Berit, Rust, Petra, Haslberger, Alexander G
Format: Article
Language:English
Subjects:
Actinin - metabolism
Adult
Alpha-Ketoglutarate-Dependent Dioxygenase FTO
biomarker
Biomarkers
Body Composition
Diet
epigenetic
Epigenetics
Exercise
Exercise - physiology
Female
fitness score
Humans
Male
Metabolism
MicroRNAs
MicroRNAs - genetics
mirnas
Nutrition
Physical fitness
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Summary:Regular, especially sustained exercise plays an important role in the prevention and treatment of multiple chronic diseases. Some of the underlying molecular and cellular mechanisms behind the adaptive response to physical activity are still unclear, but recent findings suggest a possible role of epigenetic mechanisms, especially miRNAs, in the progression and management of exercise-related changes. Due to the combination of the analysis of epigenetic biomarkers (miRNAs), the intake of food and supplements, and genetic dispositions, a "fitness score" was evaluated to assess the individual response to nutrition, exercise, and metabolic influence. In response to a 12-week sports intervention, we analyzed genetic and epigenetic biomarkers in capillary blood from 61 sedentary, healthy participants (66.1% females, 33.9% males, mean age 33 years), including methylation, three SNPs, and ten miRNAs using HRM and qPCR analysis. These biomarkers were also analyzed in a healthy, age- and sex-matched control group (n, 20) without intervention. Food frequency intake, including dietary supplement intake, and general health questionnaires were surveyed under the supervision of trained staff. Exercise training decreased the expression of miR-20a-5p, -22-5p, and -505-3p (p 
ISSN:1550-2783
1550-2783
DOI:10.1080/15502783.2022.2106148