Multiple origins of foot-and-mouth disease virus serotype Asia 1 outbreaks, 2003-2007

We investigated the molecular epidemiology of foot-and-mouth disease virus (FMDV) serotype Asia 1, which caused outbreaks of disease in Asia during 2003-2007. Since 2004, the region affected by outbreaks of this serotype has increased from disease-endemic countries in southern Asia (Afghanistan, Ind...

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Bibliographic Details
Published in:Emerging infectious diseases 2009-07, Vol.15 (7), p.1046-1051
Main Authors: Valarcher, Jean Francois, Knowles, Nick J, Zakharov, Valery, Scherbakov, Alexey, Zhang, Zhidong, Shang, You Jun, Liu, Zai Xin, Liu, Xiang Tao, Sanyal, Aniket, Hemadri, Divakar, Tosh, Chakradhar, Rasool, Thaha J, Pattnaik, Bramhadev, Schumann, Kate R, Beckham, Tammy R, Linchongsubongkoch, Wilai, Ferris, Nigel P, Roeder, Peter L, Paton, David J
Format: Article
Language:English
Subjects:
Afghanistan - epidemiology
Animals
Aphthovirus
Asia - epidemiology
Causes of
China - epidemiology
Diagnosis
Disease Outbreaks
DNA, Viral - genetics
epidemiology
Foot-and-mouth disease
Foot-and-Mouth Disease - epidemiology
Foot-and-mouth disease virus
Foot-and-Mouth Disease Virus - classification
Foot-and-Mouth Disease Virus - genetics
Genetic aspects
Geography
Health aspects
Humans
India - epidemiology
Nepal - epidemiology
Pakistan - epidemiology
Phylogeny
Physiological aspects
Picornaviridae
Reverse Transcriptase Polymerase Chain Reaction
RNA, Viral - genetics
serotype Asia 1
Serotyping
surveillance
Viral proteins
Viruses
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Summary:We investigated the molecular epidemiology of foot-and-mouth disease virus (FMDV) serotype Asia 1, which caused outbreaks of disease in Asia during 2003-2007. Since 2004, the region affected by outbreaks of this serotype has increased from disease-endemic countries in southern Asia (Afghanistan, India, Iran, Nepal, Pakistan) northward to encompass Kyrgyzstan, Tajikistan, Uzbekistan, several regions of the People's Republic of China, Mongolia, Eastern Russia, and North Korea. Phylogenetic analysis of complete virus capsid protein 1 (VP1) gene sequences demonstrated that the FMDV isolates responsible for these outbreaks belonged to 6 groups within the Asia 1 serotype. Some contemporary strains were genetically closely related to isolates collected historically from the region as far back as 25 years ago. Our analyses also indicated that some viruses have spread large distances between countries in Asia within a short time.
ISSN:1080-6040
1080-6059
DOI:10.3201/eid1507.081621