Chondroitin Sulfate Induces Depression of Synaptic Transmission and Modulation of Neuronal Plasticity in Rat Hippocampal Slices

It is currently known that in CNS the extracellular matrix is involved in synaptic stabilization and limitation of synaptic plasticity. However, it has been reported that the treatment with chondroitinase following injury allows the formation of new synapses and increased plasticity and functional r...

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Bibliographic Details
Published in:Journal of neural transplantation & plasticity 2015-01, Vol.2015 (2015), p.740-751-063
Main Authors: Albinana, Elisa, Gutierrez-Luengo, Javier, Hernandez-Juarez, Natalia, Baraibar, Andres M, Montell, Eulalia, Verges, Josep, Garcia, Antonio G, Hernandez-Guijo, Jesus M
Format: Article
Language:English
Subjects:
Animals
CA1 Region, Hippocampal - drug effects
CA1 Region, Hippocampal - physiology
Chondroitin
Chondroitin ABC Lyase - pharmacology
Chondroitin sulfate
Chondroitin Sulfates - pharmacology
Excitatory Postsynaptic Potentials - drug effects
Extracellular matrix
Hippocampus (Brain)
Long-Term Potentiation - drug effects
Male
Mental depression
Neural transmission
Neuroplasticity
Rats
Rats, Sprague-Dawley
Software
Sulfates
Synapses
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Summary:It is currently known that in CNS the extracellular matrix is involved in synaptic stabilization and limitation of synaptic plasticity. However, it has been reported that the treatment with chondroitinase following injury allows the formation of new synapses and increased plasticity and functional recovery. So, we hypothesize that some components of extracellular matrix may modulate synaptic transmission. To test this hypothesis we evaluated the effects of chondroitin sulphate (CS) on excitatory synaptic transmission, cellular excitability, and neuronal plasticity using extracellular recordings in the CA1 area of rat hippocampal slices. CS caused a reversible depression of evoked field excitatory postsynaptic potentials in a concentration-dependent manner. CS also reduced the population spike amplitude evoked after orthodromic stimulation but not when the population spikes were antidromically evoked; in this last case a potentiation was observed. CS also enhanced paired-pulse facilitation and long-term potentiation. Our study provides evidence that CS, a major component of the brain perineuronal net and extracellular matrix, has a function beyond the structural one, namely, the modulation of synaptic transmission and neuronal plasticity in the hippocampus.
ISSN:0792-8483
2090-5904
1687-5443
DOI:10.1155/2015/463854