The Role of miRNAs in Childhood Acute Lymphoblastic Leukemia Relapse and the Associated Molecular Mechanisms

Acute lymphoblastic leukemia (ALL) is the most common cancer in children worldwide. Although ALL patients' overall survival rates in wealthy countries currently surpass 80%, 15-20% of patients still experience relapse. The underlying mechanisms of relapse are still not fully understood, and lit...

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Published in:International journal of molecular sciences 2023-12, Vol.25 (1), p.119
Main Authors: Barrios-Palacios, Dalia, Organista-Nava, Jorge, Balandrán, Juan Carlos, Alarcón-Romero, Luz Del Carmen, Zubillaga-Guerrero, Ma Isabel, Illades-Aguiar, Berenice, Rivas-Alarcón, Alinne Ayulieth, Diaz-Lucas, Jessica Julieth, Gómez-Gómez, Yazmín, Leyva-Vázquez, Marco Antonio
Format: Article
Language:English
Subjects:
Acute lymphocytic leukemia
ALL
Antimitotic agents
Antineoplastic agents
B cells
Cancer therapies
Cell cycle
Chemotherapy
Childhood
Costs
Development and progression
Diseases
Drug resistance
Gene expression
Genes
Immunoglobulins
Leukemia
Lymphocytes
Medical prognosis
MicroRNA
MicroRNAs
miRNAs
Mutation
Patients
Pediatrics
Proteins
Relapse
Remission (Medicine)
resistance to therapy
Review
Steroids
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Summary:Acute lymphoblastic leukemia (ALL) is the most common cancer in children worldwide. Although ALL patients' overall survival rates in wealthy countries currently surpass 80%, 15-20% of patients still experience relapse. The underlying mechanisms of relapse are still not fully understood, and little progress has been made in treating refractory or relapsed disease. Disease relapse and treatment failure are common causes of leukemia-related death. In ALL relapse, several gene signatures have been identified, but it is also important to study miRNAs involved in ALL relapse in an effort to avoid relapse and to achieve better survival rates since miRNAs regulate target genes that participate in signaling pathways involved in relapse, such as those related to drug resistance, survival signals, and antiapoptotic mechanisms. Several miRNAs, such as miR-24, miR-27a, miR-99/100, miR-124, miR-1225b, miR-128b, miR-142-3p, miR-155 and miR-335-3p, are valuable biomarkers for prognosis and treatment response in ALL patients. Thus, this review aimed to analyze the primary miRNAs involved in pediatric ALL relapse and explore the underlying molecular mechanisms in an effort to identify miRNAs that may be potential candidates for anti-ALL therapy soon.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms25010119