Association Analyses of SNAP25, HNMT, FCHSD1 , and DBH Single-Nucleotide Polymorphisms with Parkinson's Disease in a Northern Chinese Population

• Published in: Neuropsychiatric disease and treatment 2021-01, Vol.17, p.1689-1695
• Main Authors: Dai, Cuiyun, Zhang, Yichi, Zhan, Xiaoni, Tian, Meihui, Pang, Hao
• Format: Article
• Language: English
• Subjects: association study; dbh; Dopamine; Dopamine β-monooxygenase; Enzymes; fchsd1; Gene loci; Gene polymorphism; Genetic aspects; Genome-wide association studies; Genomes; Genotyping; Histamine; hnmt; Hydroxylase; Methyltransferase; Movement disorders; N-Methyltransferase; Neurodegeneration; Neurodegenerative diseases; Neurological research; Original Research; Parkinson's disease; Polymerase chain reaction; Polymorphism; Population; Population genetics; Population studies; Restriction fragment length polymorphism; Risk factors; Single nucleotide polymorphisms; Single-nucleotide polymorphism; SNAP-25 protein; snap25; Statistical analysis
• ISSN: 1176-6328; 1178-2021; 1178-2021
• DOI: 10.2147/NDT.S304062

Sequencing potentially causal and susceptible genes and genome-wide association studies in samples from Parkinson's disease (PD) patients has revealed several related loci. The genes for synaptosome-associated protein of 25 kDa (SNAP25), histamine-N-methyltransferase (HNMT), FCH and double SH3 domains 1 (FCHSD1) and dopamine β-hydroxylase (DBH) are candidate loci and have not been studied in a northern Chinese population. We explored the genetic distribution of four single-nucleotide polymorphisms (rs3746544, rs11558538, rs456998, rs129882) located on and , respectively. A total of 330 patients with sporadic PD and 332 healthy controls (HCs) were recruited from a northern Chinese population. Polymerase chain reaction restriction fragment length polymorphism was used to genotype these four SNPs. After statistical analyses and correction of the genotyping results, the mutant-allele T in rs456998 of was found to be significantly related to reducing the PD risk ( = 0.029, OR = 0.754, 95% CI = 0.586-0.971, power = 0.591). However, rs3746544, rs11558538, and rs129882 did not show an association with PD. rs456998 may have a protective role in PD in a northern Chinese population, but more studies are needed to support this suggestion.