Myricetin bioactive effects: moving from preclinical evidence to potential clinical applications

Several flavonoids have been recognized as nutraceuticals, and myricetin is a good example. Myricetin is commonly found in plants and their antimicrobial and antioxidant activities is well demonstrated. One of its beneficial biological effects is the neuroprotective activity, showing preclinical act...

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Published in:BMC complementary and alternative medicine 2020-08, Vol.20 (1), p.241-14, Article 241
Main Authors: Taheri, Yasaman, Suleria, Hafiz Ansar Rasul, Martins, Natália, Sytar, Oksana, Beyatli, Ahmet, Yeskaliyeva, Balakyz, Seitimova, Gulnaz, Salehi, Bahare, Semwal, Prabhakar, Painuli, Sakshi, Kumar, Anuj, Azzini, Elena, Martorell, Miquel, Setzer, William N, Maroyi, Alfred, Sharifi-Rad, Javad
Format: Article
Language:English
Subjects:
Alzheimer's disease
Amyotrophic lateral sclerosis
Analgesics
Anti-Infective Agents - chemistry
Anti-Infective Agents - pharmacology
Antidiabetics
Antihypertensives
Antimicrobial
Antimicrobial agents
Antineoplastic Agents - chemistry
Antineoplastic Agents - pharmacology
Antioxidant
Antioxidants
Antioxidants - chemistry
Antioxidants - pharmacology
Biofilms
Biological effects
Cancer
Cardiovascular agents
Clinical trials
Deoxyribonucleic acid
Diabetes
Diabetes mellitus
Dietary Supplements
DNA
E coli
Flavonoids
Flavonoids - chemistry
Flavonoids - pharmacology
Fruits
Functional foods
Functional foods & nutraceuticals
Gram-positive bacteria
Humans
Huntington's chorea
Hypoglycemic Agents - chemistry
Hypoglycemic Agents - pharmacology
Immunomodulation
Isoflavones
Molecular Structure
Myricetin
Neuroprotection
Neuroprotective Agents - chemistry
Neuroprotective Agents - pharmacology
Polyphenols
Review
Salmonella
Tuberculosis
Vegetables
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Summary:Several flavonoids have been recognized as nutraceuticals, and myricetin is a good example. Myricetin is commonly found in plants and their antimicrobial and antioxidant activities is well demonstrated. One of its beneficial biological effects is the neuroprotective activity, showing preclinical activities on Alzheimer, Parkinson, and Huntington diseases, and even in amyotrophic lateral sclerosis. Also, myricetin has revealed other biological activities, among them as antidiabetic, anticancer, immunomodulatory, cardiovascular, analgesic and antihypertensive. However, few clinical trials have been performed using myricetin as nutraceutical. Thus, this review provides new insights on myricetin preclinical pharmacological activities, and role in selected clinical trials.
ISSN:2662-7671
2662-7671
1472-6882
DOI:10.1186/s12906-020-03033-z