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Common Variants in OPG Confer Risk to Bone Mineral Density Variation and Osteoporosis Fractures
Although many common variants have been identified for bone mineral density (BMD) and osteoporosis fractures, all the identified risk variants could only explain a small portion of heritability of BMD and osteoporosis fractures. OPG belongs to the tumor necrosis factor receptor superfamily, which pl...
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| Published in: | Scientific reports 2017-05, Vol.7 (1), p.1739-7, Article 1739 |
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| description | Although many common variants have been identified for bone mineral density (BMD) and osteoporosis fractures, all the identified risk variants could only explain a small portion of heritability of BMD and osteoporosis fractures.
OPG
belongs to the tumor necrosis factor receptor superfamily, which plays a crucial role in bone remodeling and is thus a promising candidate gene of osteoporosis. Several studies have explored the association of OPG variants with BMD or osteoporosis fractures, however, the results remain inconsistent among different populations. In the study, we first assessed the relationship between OPG variants and BMD or osteoporosis fractures in our sample size (227 subjects with postmenopausal osteoporosis and 189 controls), and then performed a systematic meta-analysis. Among the nine SNPs genotyped, rs6469804 and rs2073618 showed significant associations with both BMD and osteoporotic fractures, while rs3102735 was only associated with BMD in our samples (
P
|
| doi_str_mv | 10.1038/s41598-017-01579-6 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_doaj_</sourceid><recordid>TN_cdi_doaj_primary_oai_doaj_org_article_cffb6c8ee0a14113bd5005c8f3594d22</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><doaj_id>oai_doaj_org_article_cffb6c8ee0a14113bd5005c8f3594d22</doaj_id><sourcerecordid>1963162416</sourcerecordid><originalsourceid>FETCH-LOGICAL-c507t-3063a6f43d64b705ad0b2010adb15e5a306ff75ff7f8be59016752a900d52ee03</originalsourceid><addsrcrecordid>eNp1kV1rVDEQhoMottT-AS8k4PWx-T4nN4Ju7QdUVkS9DTknkzXrbrImWaH_3rSnlu2FgSEhM-8zmbwIvabkHSV8OCuCSj10hPYtZK879QwdMyJkxzhjzw_OR-i0lDVpSzItqH6JjtggtGKEHyOzSNttiviHzcHGWnCIePnlEi9S9JDx11B-4ZrwxxQBfw4Rst3gc4gl1NtZU0NT2-jwslRIu5RTCQVfZDvVfYbyCr3wdlPg9GE_Qd8vPn1bXHU3y8vrxYebbpKkrx0nilvlBXdKjD2R1pGREUqsG6kEaVve-1628MMIUhOqesmsJsRJBkD4CbqeuS7ZtdnlsLX51iQbzP1Fyitjcw3TBszk_aimoaksFZTy0cn2NdPgudTCMdZY72fWbj9uwU0Qaxv7CfRpJoafZpX-GCk4a6gGePsAyOn3Hko167TPsc1vqFacKiaoalVsrpran5UM_rEDJebOYzN7bJrH5t5jcyd6c_i2R8k_R1sBnwtKS8UV5IPe_8f-Bc71sd0</addsrcrecordid><sourcetype>Open Website</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1963162416</pqid></control><display><type>article</type><title>Common Variants in OPG Confer Risk to Bone Mineral Density Variation and Osteoporosis Fractures</title><source>Open Access: PubMed Central</source><source>Publicly Available Content Database</source><source>Free Full-Text Journals in Chemistry</source><source>Springer Nature - nature.com Journals - Fully Open Access</source><creator>Sheng, Xiaoyong ; Cai, Guangyong ; Gong, Xingjun ; Yao, Zouying ; Zhu, Ye</creator><creatorcontrib>Sheng, Xiaoyong ; Cai, Guangyong ; Gong, Xingjun ; Yao, Zouying ; Zhu, Ye</creatorcontrib><description>Although many common variants have been identified for bone mineral density (BMD) and osteoporosis fractures, all the identified risk variants could only explain a small portion of heritability of BMD and osteoporosis fractures.
OPG
belongs to the tumor necrosis factor receptor superfamily, which plays a crucial role in bone remodeling and is thus a promising candidate gene of osteoporosis. Several studies have explored the association of OPG variants with BMD or osteoporosis fractures, however, the results remain inconsistent among different populations. In the study, we first assessed the relationship between OPG variants and BMD or osteoporosis fractures in our sample size (227 subjects with postmenopausal osteoporosis and 189 controls), and then performed a systematic meta-analysis. Among the nine SNPs genotyped, rs6469804 and rs2073618 showed significant associations with both BMD and osteoporotic fractures, while rs3102735 was only associated with BMD in our samples (
P
< 0.05). For meta-analyses, data for a total of 12 SNPs were pooled (4725 patients and 37804 controls), and five SNPs, including rs6993813, rs6469804, rs3134070, rs2073618 and rs3102734, showed association with osteoporosis fractures (
P
< 0.05). On light of the above analysis, we believe that OPG is one promising susceptibility gene of BMD or osteoporotic fractures.</description><identifier>ISSN: 2045-2322</identifier><identifier>EISSN: 2045-2322</identifier><identifier>DOI: 10.1038/s41598-017-01579-6</identifier><identifier>PMID: 28496203</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>45/22 ; 45/23 ; 45/77 ; 631/208/727/2000 ; 692/499 ; Aged ; Bone density ; Bone Density - genetics ; Bone mineral density ; Bone remodeling ; Data processing ; Demography ; Female ; Fractures ; Genetic Predisposition to Disease ; Heritability ; Humanities and Social Sciences ; Humans ; multidisciplinary ; Osteoporosis ; Osteoporotic Fractures - genetics ; Osteoporotic Fractures - physiopathology ; Osteoprotegerin ; Osteoprotegerin - genetics ; Polymorphism, Single Nucleotide - genetics ; Population studies ; Post-menopause ; Postmenopause - genetics ; Risk Factors ; Science ; Science (multidisciplinary) ; Single-nucleotide polymorphism</subject><ispartof>Scientific reports, 2017-05, Vol.7 (1), p.1739-7, Article 1739</ispartof><rights>The Author(s) 2017</rights><rights>Copyright Nature Publishing Group May 2017</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c507t-3063a6f43d64b705ad0b2010adb15e5a306ff75ff7f8be59016752a900d52ee03</citedby><cites>FETCH-LOGICAL-c507t-3063a6f43d64b705ad0b2010adb15e5a306ff75ff7f8be59016752a900d52ee03</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.proquest.com/docview/1963162416/fulltextPDF?pq-origsite=primo$$EPDF$$P50$$Gproquest$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/1963162416?pq-origsite=primo$$EHTML$$P50$$Gproquest$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,25752,27923,27924,37011,44589,53790,53792,74897</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28496203$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sheng, Xiaoyong</creatorcontrib><creatorcontrib>Cai, Guangyong</creatorcontrib><creatorcontrib>Gong, Xingjun</creatorcontrib><creatorcontrib>Yao, Zouying</creatorcontrib><creatorcontrib>Zhu, Ye</creatorcontrib><title>Common Variants in OPG Confer Risk to Bone Mineral Density Variation and Osteoporosis Fractures</title><title>Scientific reports</title><addtitle>Sci Rep</addtitle><addtitle>Sci Rep</addtitle><description>Although many common variants have been identified for bone mineral density (BMD) and osteoporosis fractures, all the identified risk variants could only explain a small portion of heritability of BMD and osteoporosis fractures.
OPG
belongs to the tumor necrosis factor receptor superfamily, which plays a crucial role in bone remodeling and is thus a promising candidate gene of osteoporosis. Several studies have explored the association of OPG variants with BMD or osteoporosis fractures, however, the results remain inconsistent among different populations. In the study, we first assessed the relationship between OPG variants and BMD or osteoporosis fractures in our sample size (227 subjects with postmenopausal osteoporosis and 189 controls), and then performed a systematic meta-analysis. Among the nine SNPs genotyped, rs6469804 and rs2073618 showed significant associations with both BMD and osteoporotic fractures, while rs3102735 was only associated with BMD in our samples (
P
< 0.05). For meta-analyses, data for a total of 12 SNPs were pooled (4725 patients and 37804 controls), and five SNPs, including rs6993813, rs6469804, rs3134070, rs2073618 and rs3102734, showed association with osteoporosis fractures (
P
< 0.05). On light of the above analysis, we believe that OPG is one promising susceptibility gene of BMD or osteoporotic fractures.</description><subject>45/22</subject><subject>45/23</subject><subject>45/77</subject><subject>631/208/727/2000</subject><subject>692/499</subject><subject>Aged</subject><subject>Bone density</subject><subject>Bone Density - genetics</subject><subject>Bone mineral density</subject><subject>Bone remodeling</subject><subject>Data processing</subject><subject>Demography</subject><subject>Female</subject><subject>Fractures</subject><subject>Genetic Predisposition to Disease</subject><subject>Heritability</subject><subject>Humanities and Social Sciences</subject><subject>Humans</subject><subject>multidisciplinary</subject><subject>Osteoporosis</subject><subject>Osteoporotic Fractures - genetics</subject><subject>Osteoporotic Fractures - physiopathology</subject><subject>Osteoprotegerin</subject><subject>Osteoprotegerin - genetics</subject><subject>Polymorphism, Single Nucleotide - genetics</subject><subject>Population studies</subject><subject>Post-menopause</subject><subject>Postmenopause - genetics</subject><subject>Risk Factors</subject><subject>Science</subject><subject>Science (multidisciplinary)</subject><subject>Single-nucleotide polymorphism</subject><issn>2045-2322</issn><issn>2045-2322</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>PIMPY</sourceid><sourceid>DOA</sourceid><recordid>eNp1kV1rVDEQhoMottT-AS8k4PWx-T4nN4Ju7QdUVkS9DTknkzXrbrImWaH_3rSnlu2FgSEhM-8zmbwIvabkHSV8OCuCSj10hPYtZK879QwdMyJkxzhjzw_OR-i0lDVpSzItqH6JjtggtGKEHyOzSNttiviHzcHGWnCIePnlEi9S9JDx11B-4ZrwxxQBfw4Rst3gc4gl1NtZU0NT2-jwslRIu5RTCQVfZDvVfYbyCr3wdlPg9GE_Qd8vPn1bXHU3y8vrxYebbpKkrx0nilvlBXdKjD2R1pGREUqsG6kEaVve-1628MMIUhOqesmsJsRJBkD4CbqeuS7ZtdnlsLX51iQbzP1Fyitjcw3TBszk_aimoaksFZTy0cn2NdPgudTCMdZY72fWbj9uwU0Qaxv7CfRpJoafZpX-GCk4a6gGePsAyOn3Hko167TPsc1vqFacKiaoalVsrpran5UM_rEDJebOYzN7bJrH5t5jcyd6c_i2R8k_R1sBnwtKS8UV5IPe_8f-Bc71sd0</recordid><startdate>20170511</startdate><enddate>20170511</enddate><creator>Sheng, Xiaoyong</creator><creator>Cai, Guangyong</creator><creator>Gong, Xingjun</creator><creator>Yao, Zouying</creator><creator>Zhu, Ye</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><general>Nature Portfolio</general><scope>C6C</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>88I</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>M7P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20170511</creationdate><title>Common Variants in OPG Confer Risk to Bone Mineral Density Variation and Osteoporosis Fractures</title><author>Sheng, Xiaoyong ; Cai, Guangyong ; Gong, Xingjun ; Yao, Zouying ; Zhu, Ye</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c507t-3063a6f43d64b705ad0b2010adb15e5a306ff75ff7f8be59016752a900d52ee03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>45/22</topic><topic>45/23</topic><topic>45/77</topic><topic>631/208/727/2000</topic><topic>692/499</topic><topic>Aged</topic><topic>Bone density</topic><topic>Bone Density - genetics</topic><topic>Bone mineral density</topic><topic>Bone remodeling</topic><topic>Data processing</topic><topic>Demography</topic><topic>Female</topic><topic>Fractures</topic><topic>Genetic Predisposition to Disease</topic><topic>Heritability</topic><topic>Humanities and Social Sciences</topic><topic>Humans</topic><topic>multidisciplinary</topic><topic>Osteoporosis</topic><topic>Osteoporotic Fractures - genetics</topic><topic>Osteoporotic Fractures - physiopathology</topic><topic>Osteoprotegerin</topic><topic>Osteoprotegerin - genetics</topic><topic>Polymorphism, Single Nucleotide - genetics</topic><topic>Population studies</topic><topic>Post-menopause</topic><topic>Postmenopause - genetics</topic><topic>Risk Factors</topic><topic>Science</topic><topic>Science (multidisciplinary)</topic><topic>Single-nucleotide polymorphism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sheng, Xiaoyong</creatorcontrib><creatorcontrib>Cai, Guangyong</creatorcontrib><creatorcontrib>Gong, Xingjun</creatorcontrib><creatorcontrib>Yao, Zouying</creatorcontrib><creatorcontrib>Zhu, Ye</creatorcontrib><collection>SpringerOpen</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Databases</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>PML(ProQuest Medical Library)</collection><collection>Science Database</collection><collection>Biological Science Database</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>Scientific reports</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sheng, Xiaoyong</au><au>Cai, Guangyong</au><au>Gong, Xingjun</au><au>Yao, Zouying</au><au>Zhu, Ye</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Common Variants in OPG Confer Risk to Bone Mineral Density Variation and Osteoporosis Fractures</atitle><jtitle>Scientific reports</jtitle><stitle>Sci Rep</stitle><addtitle>Sci Rep</addtitle><date>2017-05-11</date><risdate>2017</risdate><volume>7</volume><issue>1</issue><spage>1739</spage><epage>7</epage><pages>1739-7</pages><artnum>1739</artnum><issn>2045-2322</issn><eissn>2045-2322</eissn><abstract>Although many common variants have been identified for bone mineral density (BMD) and osteoporosis fractures, all the identified risk variants could only explain a small portion of heritability of BMD and osteoporosis fractures.
OPG
belongs to the tumor necrosis factor receptor superfamily, which plays a crucial role in bone remodeling and is thus a promising candidate gene of osteoporosis. Several studies have explored the association of OPG variants with BMD or osteoporosis fractures, however, the results remain inconsistent among different populations. In the study, we first assessed the relationship between OPG variants and BMD or osteoporosis fractures in our sample size (227 subjects with postmenopausal osteoporosis and 189 controls), and then performed a systematic meta-analysis. Among the nine SNPs genotyped, rs6469804 and rs2073618 showed significant associations with both BMD and osteoporotic fractures, while rs3102735 was only associated with BMD in our samples (
P
< 0.05). For meta-analyses, data for a total of 12 SNPs were pooled (4725 patients and 37804 controls), and five SNPs, including rs6993813, rs6469804, rs3134070, rs2073618 and rs3102734, showed association with osteoporosis fractures (
P
< 0.05). On light of the above analysis, we believe that OPG is one promising susceptibility gene of BMD or osteoporotic fractures.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>28496203</pmid><doi>10.1038/s41598-017-01579-6</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | 45/22 45/23 45/77 631/208/727/2000 692/499 Aged Bone density Bone Density - genetics Bone mineral density Bone remodeling Data processing Demography Female Fractures Genetic Predisposition to Disease Heritability Humanities and Social Sciences Humans multidisciplinary Osteoporosis Osteoporotic Fractures - genetics Osteoporotic Fractures - physiopathology Osteoprotegerin Osteoprotegerin - genetics Polymorphism, Single Nucleotide - genetics Population studies Post-menopause Postmenopause - genetics Risk Factors Science Science (multidisciplinary) Single-nucleotide polymorphism |
| title | Common Variants in OPG Confer Risk to Bone Mineral Density Variation and Osteoporosis Fractures |
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