Pathophysiological and diagnostic importance of fatty acid-binding protein 1 in heart failure with preserved ejection fraction

Elevated intracardiac pressure at rest and/or exercise is a fundamental abnormality in heart failure with preserved ejection fraction (HFpEF). Fatty acid-binding protein 1 (FABP1) is proposed to be a sensitive biomarker for liver injury. We sought to determine whether FABP1 at rest would be elevated...

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Published in:Scientific reports 2021-10, Vol.11 (1), p.21175-21175, Article 21175
Main Authors: Harada, Tomonari, Araki, Takeshi, Sunaga, Hiroaki, Kagami, Kazuki, Yoshida, Kuniko, Kato, Toshimitsu, Kawakami, Ryo, Tomono, Junichi, Wada, Naoki, Iso, Tatsuya, Kurabayashi, Masahiko, Obokata, Masaru
Format: Article
Language:English
Subjects:
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Aged
Bicycles
Biomarkers
Biomarkers - blood
Blood Pressure
Cardiac Output
Congestive heart failure
Echocardiography
Ejection fraction
Exercise Test
Fatty acid-binding protein
Fatty Acid-Binding Proteins - blood
Fatty acids
Female
Heart failure
Heart Failure - blood
Heart Failure - diagnosis
Heart Failure - diagnostic imaging
Humanities and Social Sciences
Humans
Liver
Male
Middle Aged
multidisciplinary
Pulmonary arteries
Pulmonary artery
Science
Science (multidisciplinary)
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Summary:Elevated intracardiac pressure at rest and/or exercise is a fundamental abnormality in heart failure with preserved ejection fraction (HFpEF). Fatty acid-binding protein 1 (FABP1) is proposed to be a sensitive biomarker for liver injury. We sought to determine whether FABP1 at rest would be elevated in HFpEF and would correlate with echocardiographic markers of intracardiac pressures at rest and during exercise. In this prospective study, subjects with HFpEF (n = 22) and control subjects without HF (n = 23) underwent resting FABP1 measurements and supine bicycle exercise echocardiography. Although levels of conventional hepatic enzymes were similar between groups, FABP1 levels were elevated in HFpEF compared to controls (45 [25–68] vs. 18 [14–24] ng/mL, p  = 0.0008). FABP1 levels were correlated with radiographic and blood-based markers of congestion, hemodynamic derangements during peak exercise (E/e’, r = 0.50; right atrial pressure, r = 0.35; pulmonary artery systolic pressure, r = 0.46), reduced exercise cardiac output (r = − 0.49), and poor exercise workload achieved (r = − 0.40, all p  
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-021-00760-2