MicroRNA biogenesis pathway genes polymorphisms and cancer risk: a systematic review and meta-analysis

MicroRNAs (miRNAs) may promote the development and progression of human cancers. Therefore, components of the miRNA biogenesis pathway may play critical roles in human cancer. Single nucleotide polymorphisms (SNPs) or mutations in genes involved in the miRNA biogenesis pathway may alter levels of ge...

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Bibliographic Details
Published in:PeerJ (San Francisco, CA) CA), 2016-12, Vol.4, p.e2706-e2706, Article e2706
Main Authors: He, Jieyu, Zhao, Jun, Zhu, Wenbo, Qi, Daxun, Wang, Lina, Sun, Jinfang, Wang, Bei, Ma, Xu, Dai, Qiaoyun, Yu, Xiaojin
Format: Article
Language:English
Subjects:
Binding sites
Biosynthesis
Bladder cancer
Breast cancer
Cancer
Cancer genetics
Cancer research
Cancer risk
Colorectal cancer
Development and progression
Disease prevention
Disease susceptibility
Enzymes
Epidemiology
Esophageal cancer
Evidence Based Medicine
Evolution
Gastric cancer
Gene expression
Genes
Genetic aspects
Genetic diversity
Genetics
Health aspects
Health risk assessment
Lung cancer
Medical research
Meta-analysis
MicroRNA
MicroRNA biogenesis
MicroRNAs
miRNA
Oncology
Proteins
Risk factors
RNA polymerase
Single nucleotide polymorphisms
Single-nucleotide polymorphism
Studies
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Summary:MicroRNAs (miRNAs) may promote the development and progression of human cancers. Therefore, components of the miRNA biogenesis pathway may play critical roles in human cancer. Single nucleotide polymorphisms (SNPs) or mutations in genes involved in the miRNA biogenesis pathway may alter levels of gene expression, affecting disease susceptibility. Results of previous studies on genetic variants in the miRNA biogenesis pathway and cancer risk were inconsistent. Therefore, a meta-analysis is needed to assess the associations of these genetic variants with human cancer risk. We searched for relevant articles from PubMed, Web of Science, CNKI, and CBM through Jun 21, 2016. In total, 21 case-control articles met all of the inclusion criteria for the study. Significant associations were observed between cancer risk and the polymorphism rs417309 G >A (OR 1.22, 95% CI [1.04-1.42]), as well as the polymorphism rs1057035 TT (OR 1.13, 95% CI [1.05-1.22]). These SNPs exhibit high potential as novel diagnostic markers. Future studies with larger sample sizes and more refined analyses are needed to shed more light on these findings.
ISSN:2167-8359
2167-8359
DOI:10.7717/peerj.2706