Cardiac Amyloidosis with Normal Wall Thickness: Prevalence, Clinical Characteristics and Outcome in a Retrospective Analysis

Background: Cardiac amyloidosis (CA) is a rare, progressive, infiltrative cardiac disease. Light chain (AL) and transthyretin (ATTR) amyloidosis are in the background in almost all cases. New, easily available diagnostic tools and recently introduced novel therapies for both types of CA put this dis...

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Published in:Biomedicines 2022-07, Vol.10 (7), p.1765
Main Authors: Nagy, Daniella, Révész, Katalin, Peskó, Gergely, Varga, Gergely, Horváth, Laura, Farkas, Péter, Tóth, András Dávid, Sepp, Róbert, Vágó, Hajnalka, Nagy, Anikó Ilona, Masszi, Tamás, Pozsonyi, Zoltán
Format: Article
Language:English
Subjects:
AL amyloidosis
Amyloidosis
Aortic stenosis
ATTR amyloidosis
Biomarkers
Biopsy
cardiac amyloidosis
Cardiac arrhythmia
cardiac imaging
Cardiomyopathy
Coronary artery disease
Disease
Echocardiography
Heart diseases
Laboratories
left ventricular wall thickness
Medical prognosis
Medicin och hälsovetenskap
Patients
Reproducibility
Transthyretin
Ventricle
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Summary:Background: Cardiac amyloidosis (CA) is a rare, progressive, infiltrative cardiac disease. Light chain (AL) and transthyretin (ATTR) amyloidosis are in the background in almost all cases. New, easily available diagnostic tools and recently introduced novel therapies for both types of CA put this disease into the field of interest. Increased left ventricular wall thickness (IWT) detected by echocardiography is generally thought to be a necessary part of the diagnosis. We aimed to determine the proportion of CA patients without IWT, and to define the clinical characteristics of this cohort. Methods: In an academic tertiary center for CA, we identified patients diagnosed and treated for CA between January 2009 and February 2022. In a retrospective analysis we defined the proportion of patients with (≥12 mm) and without (
ISSN:2227-9059
2227-9059
DOI:10.3390/biomedicines10071765