Sucralose: From Sweet Success to Metabolic Controversies-Unraveling the Global Health Implications of a Pervasive Non-Caloric Artificial Sweetener

Sucralose is a food additive initially used to mitigate glycemic peaks and calorie intake in patients with diabetes and obesity. Although sucralose has been considered safe for human consumption, the World Health Organization (WHO) issued a global alert in 2023 concerning the potential health implic...

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Bibliographic Details
Published in:Life (Basel, Switzerland) Switzerland), 2024-02, Vol.14 (3), p.323
Main Authors: Aguayo-Guerrero, José Alfredo, Méndez-García, Lucía Angélica, Solleiro-Villavicencio, Helena, Viurcos-Sanabria, Rebeca, Escobedo, Galileo
Format: Article
Language:English
Subjects:
Artificial sweeteners
Body fat
Brain research
Complications and side effects
Development and progression
Diabetes
Diabetes mellitus
Diet
Dysbacteriosis
Food
Food additives
Global health
Glucose
Health aspects
Impact damage
Inflammation
Inflammatory response
insulin resistance
liver damage
Metabolic diseases
Metabolic disorders
Metabolites
Microbiomes
microbiota
Motility
Neuropeptides
non-caloric artificial sweeteners
Obesity
Proteins
Public health
Review
Risk factors
Satiety
Small intestine
Sucralose
Sucrose
Sweet taste
T1R3
Taste receptors
Toxicity
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Summary:Sucralose is a food additive initially used to mitigate glycemic peaks and calorie intake in patients with diabetes and obesity. Although sucralose has been considered safe for human consumption, the World Health Organization (WHO) issued a global alert in 2023 concerning the potential health implications of this artificial sweetener. This review aims to comprehensively explore the effects of sucralose intake on human health by understanding sucralose absorption, metabolism, and excretion. We also outline the role of the sweet taste 1 receptor 3 (T1R3) in mediating sucralose-dependent signaling pathways that regulate satiety, incretin release, and insulin response. Finally, we discuss the impact of sucralose on microbiome dysbiosis, inflammatory response origin, liver damage, and toxicity. Gaining a deeper understanding of the manifold effects of sucralose on human physiology will help promote further studies to ensure its consumption is deemed safe for a broader population, including children, adolescents, and pregnant women.
ISSN:2075-1729
2075-1729
DOI:10.3390/life14030323